2025-523374-17-01撤回4 期
Insulin resistance in type 2 diabetes: evaluating the pathogenic mechanisms of insulin resistance in the myocardium and the effects of the treatments with GLP-1RA and SGLT2i
Fundacio Hospital Universitari Vall D’Hebron Institut De Recerca1 个研究点 分布在 1 个国家目标入组 60 人开始时间: 2025年12月23日最近更新:
试验速览
- 阶段
- 4 期
- 状态
- 撤回
- 发起方
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Myocardium insulin resistance
研究概览
简要总结
To determine by means of 18F-FDG PET/CT and 99mTc-Tetrofosmin SPECT whether myocardial IR affects cardiac function and coronary flow and is therefore a risk factor for cardiovascular events and diabetic cardiomyopathy in DM2 patients with myocardial IR phenotype
入排标准
- 年龄范围
- 18 years 至 65+ years（18-64 Years, 65+ Years）
- 接受健康志愿者
- 否
入选标准
- •BMI around 30 kg/m2
- •no-smoking; no-alcohol
- •HbA1c between 7-9%
排除标准
- •previous CVD events
- •hepatic and kidney complications
- •claustrophobia to PET/CT and SPECT
- •treatment with SGLT2 inhibitors or GLP-1 analogs.
结局指标
主要结局
Myocardium insulin resistance
Myocardium insulin resistance
次要结局
- Coronary flow
- Heart function
研究者
Olga Simó Servat
Scientific
Fundacio Hospital Universitari Vall D’Hebron Institut De Recerca
研究点 (1)
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