Genetics of EGFR (Epidermal Growth Factor Receptor) Mutation Study
- Conditions
- EGFR Mutation Positive Non Small Cell Lung Cancer
- Registration Number
- NCT01838577
- Brief Summary
The investigators wish to document the distribution of EGFR somatic mutations, and assess the relationship between specific genotype, clinical demographic, therapy, and survival, in a large cohort of EGFR mutant NSCLC.
The investigators also wish to comprehensively investigate the relationship between germline DNA and risk of EGFR mutant NSCLC developing, through a GWAS (Genome-Wide Association Studies) and candidate gene approach, and explore the relationship between germline DNA and clinical outcome, in order to potentially identify germline genetic modifiers of EGFR TKI (Tyrosine Kinase Inhibitor) outcome.
- Detailed Description
Objective 1: To identify germline allelic DNA variation associated with somatic EGFR mutation in NSCLC, Objective 2: Correlation between germline allelic variants and survival in EGFR somatic mutant NSCLC.
Objective 3: Study germline allelic DNA variation associated with never /ex light smoking NSCLC.
Objective 4: Catalogue distribution of somatic EGFR mutant genotypes in 1,000 EGFR mutant NSCLC cases and describe their relationship to clinical outcome.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 2000
Not provided
Not provided
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method For the second objective, the primary endpoint is Overall survival (OS) 5 years from FPI
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Royal Marsden
🇬🇧Sutton, United Kingdom