Effect of on combination therapy with irbesartan and amlodipine besilate on clinical blood pressure, home blood pressure and blood pressure variability in hypertensive patients with chronic kidney disease
Not Applicable
Recruiting
- Conditions
- Hypertension with chronic kidney disease (CKD G1-G4)
- Registration Number
- JPRN-UMIN000013213
- Lead Sponsor
- Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 30
Inclusion Criteria
Not provided
Exclusion Criteria
1) CKD G5 or dialysis patients. 2) Patients who have allergy for amlodipine besilate or irbesartan. 3) Patients who are pregnant. 4) Patients judged as inappropriate for the study.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Efficacy: Change in the following from baseline to Week 4,8,12: -Clinical blood pressure, within visit blood pressure variability -Home blood pressure, home blood pressure variability -Nighttime blood pressure, nighttime blood pressure variability Efficacy: Change in the following from baseline to Week 12: -Body weight, obesity, abdominal circumference -Laboratory parameters (renal function, oxidative stress etc.) -Vascular function (AI, ABI/PWV, CAVI)
- Secondary Outcome Measures
Name Time Method