COACH-pilot study; COgnition After intraCerebral Hemorrhage
- Conditions
- Intracerebral hemorrhage and dementia
- Registration Number
- NL-OMON23317
- Lead Sponsor
- MC
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 32
ICH patients:
1. Age = 55y 2. Ability and willingness to provide written informed consent. 3. Supratentorial ICH with CAAa or HAb as the most likely cause.
a CAA-related ICH is defined as an ICH that meets the criteria for definite or probable CAA according to the Modified Boston Criteria (appendix A) b HA-related ICH is defined as ICH located in the basal ganglia, thalamus, or the deep white matter and the presence of hypertension defined as: on treatment for hypertension, or known with high blood pressure (two measurements SBP >140 or DBP >90 mmHg) but not treated for hypertension.
5.3 Exclusion criteria
1. Age < 55y
2. Unable to provide informed consent.
3. Pre-existing cognitive impairment assessed with the Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE); scores between 53 - 63 reflect pre-existing cognitive mpairment.
4. Contra indications, such as: Contra-indications for 3T MRI and contraindications for lumbar puncture:
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The main parameters are cognitive decline (according to the neuropsychological assessment) at 12 months.
- Secondary Outcome Measures
Name Time Method Secondary outcomes are burden of SVD markers on MRI and CSF markers at baseline, at six months and 12 months.