Platelet reactivity over time in patients undergoing vascular surgery

Recruiting

• Conditions: 10003216; antiplatelet therapy; atherosclerosis

• Registration Number: NL-OMON46079
• Lead Sponsor: niversitair Medisch Centrum Utrecht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 50

Inclusion Criteria

-Taking antiplatelet therapy
- Undergoing elective carotid endarterectomy
- Admitted to the hospital at least 1 day postoperative
- older than 18 years

Exclusion Criteria

- indication for postoperative Intensive Care opname
- are treated with vitamine K antagonists
- Need of per- or postoperative blood transfusion

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Platelet reactivity (measured by VerifyNow, VASP and PACT) at four different<br /><br>time points in patients undergoing carotid endarterectomy (CEA) and are treated<br /><br>with aspirin + P2Y12 inhibitor</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Early thrombotic cardiovascular events (<2.5 months after surgery):<br /><br>cardiovascular death, transient ischemic attack, stroke, myocardial infarction,<br /><br>stent thrombosis, acute limb ischemia and the need for peripheral<br /><br>revascularization<br /><br><br /><br>Early bleeding complications (<2.5 months after surgery): secondary bleeding<br /><br>after surgery, gastrointestinal bleeding and brain hemorrhage.<br /><br><br /><br>Presence of a known CYP2C19 mutation<br /><br><br /><br>Quantification of platelet markers as (beta-thromboglobulin, platelet derived<br /><br>growth factor, RANTES and platelet- factor 4). </p><br>