Assessment of immuno-metabolic axis of Autoimmune Blistering Diseases (AIBDs) – Mechanistic and diagnostic implications
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 42
- 试验地点
- 1
- 主要终点
- to study the difference between cytokine and metabolomic profiles of patients with autoimmune blistering disorders with that of control group
研究概览
简要总结
Through this cross-sectional comparative study, we intend to compare the cytokine and metabolic profile of the pemphigus and pemphigoid group of patients with the control group.This study will be conducted over two years, with a sample size of 42 (21 in each group). 21 new cases of Pemphigus (and its variants) and Pemphigoid group of diseases, diagnosed by immunofluorescence studies (DIF/IIF) or serological methods, and consenting to participate in the study will be included in the case group. 21 age and sex-matched controls will also be recruited. Cytokine and metabolomic analysis will be carried out on all participants and the results obtained will be analyzed by statistical tools such as R, Mass Profiler Plus, and SPSS. All the analyzed data will be interpreted and reported. Thus by this study, we intend to add information to the literature regarding the role of cytokine profile in these conditions, which may be helpful in the future for coming up with treatment modalities targeting this pathway.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 1.00 Day(s) 至 99.00 Year(s)（—）
- 性别
- All
入选标准
- •All new cases of Pemphigus (and its variants) and Pemphigoid group of diseases diagnosed by immunofluorescence studies(DIF/IIF) or serological methods.
排除标准
- •Patients unwilling to give consent for the study or investigations.
- •Patients who are in remission.
结局指标
主要结局
to study the difference between cytokine and metabolomic profiles of patients with autoimmune blistering disorders with that of control group
时间窗: at first presentation to the principle investigator
次要结局
- to study the difference between the cytokine & metabolomic profile of pemphigus & pemphigoid group of conditions(over a period of 2 years)
研究者
Dr Raghavendra Rao
Kasturba Medical College Manipal