A Comprehensive (Pharmaceuitical, Analytical and Clinical)study of Madayantivaatari taila in Sandhivata(Osteoarthritis)
试验速览
- 阶段
- 2 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 90
- 试验地点
- 1
- 主要终点
- Reduction in pain at affected joints,improvement in movement,stiffness and swelling at affected joints
研究概览
简要总结
Osteoarthritis is by far the most common form of arthritis and is a major cause of pain and disability in older people and is characterized by focal loss of articular cartilage, subchondral osteosclerosis, osteophyte formation at the joint margin, and remodeling of joint contour with enlargement of affected joints. OA affects over 32.5 million US adults.Investigators found that globally, prevalent cases of osteoarthritis increased by 113.25 percent from 247.51 million in 1990 to 527.81 million in 2019.
Osteoarthritis (OA) is the most prevalent chronic joint disease and remains one of the few chronic disorders of ageing for which there is little effective treatment and none proven that delays disease progression. It can affect small, medium, and large joints though, in terms of a painful disease, the knee is the most frequently affected with up to one in eight men and women over the age of 60 years having evidence of symptomatic knee OA. OA is a leading cause of disability in older adults and is one of the leading causes of impairment of mobility in the elderly population in the USA. It accounts also for substantial direct healthcare costs related largely to the requirement for joint replacement surgery in those with end-stage disease.
Sandhigata Vata /Sandhivata has been told by Acharya Charaka in the chapter of “Vatavyadhi Chitiksaâ€. Its features resemble osteoarthritis as per Modern science. It means a condition in which morbid Vata gets located in joints and hinders the functioning of joints. The vitiated Vata on getting lodged in the joints of the body causes Sandhigata Vata.वातपूरà¥à¤£à¤¦à¥ƒà¤¤à¤¿à¤¸à¥à¤ªà¤°à¥à¤¶à¤ƒà¤¶à¥‹à¤¥à¤ƒà¤¸à¤¨à¥à¤§à¤¿à¤—तेऽनिले****| पà¥à¤°à¤¸à¤¾à¤°à¤£à¤¾à¤•à¥à¤žà¥à¤šà¤¨à¤¯à¥‹à¤ƒà¤ªà¥à¤°à¤µà¥ƒà¤¤à¥à¤¤à¤¿à¤¶à¥à¤šà¤¸à¤µà¥‡à¤¦à¤¨à¤¾**||** (च.चि २८/३7)
The symptoms explained by Acharya Charaka are as follows-
· Vatapurna - Pain
· Vatapurna Driti Sparsha*-* sounds resembling that made when we rub against a transparent container filled with air.
· Shotha - Swelling
· Prasarana akunchanayoho pravritti- including painful extension and flexion.
研究设计
- 研究类型
- Interventional
- 分配方式
- Coin toss, Lottery, toss of dice, shuffling cards etc
- 盲法
- Participant Blinded
入排标准
- 年龄范围
- 40.00 Year(s) 至 80.00 Year(s)（—）
- 性别
- All
入选标准
- •â€¢Pain area-In the joint,hand ,hip, knee, lower back or neck •Patient without any Anatomical deformity.
- •â€¢Pain •Stiffness •Tenderness •Loss of Flexibility •Grating sensation •Swelling.
排除标准
- •1-Patients not full filling the inclusion criteria.
- •2-Patients of age less than 40 and more than 80 years.
- •3-Patient with secondary osteoarthritis , Rheumatoid arthritis , Gouty arthritis.
- •4-Patient with a recent history of Any Trauma on knee joint.
结局指标
主要结局
Reduction in pain at affected joints,improvement in movement,stiffness and swelling at affected joints
时间窗: 21 days
次要结局
- Reduction in score of VAS scale of pain , Increase in range of improvement of affected joints measured by goniometer, crepitus will be reduced or stop after using this taila(2 month)