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临床试验/NCT03822923
NCT03822923
已完成
不适用

Effects of Neurodynamics on Spasticity in Upper Extremity of Stroke Patients.

Riphah International University1 个研究点 分布在 1 个国家目标入组 41 人2019年1月23日
适应症Stroke

概览

阶段
不适用
干预措施
未指定
疾病 / 适应症
Stroke
发起方
Riphah International University
入组人数
41
试验地点
1
主要终点
Modified Ashwarth Scale
状态
已完成
最后更新
6年前

概览

简要总结

Data will be collected from 40 patients with hemiplegia, caused by stroke from DHQ hospital Jhelum. its an RCT Neurodynamics with conventional treatment to experimental group and conventional treatment alone to control group will be applied for 6 weeks.

Simple random sampling will be done and randomization will be done through tossing a coin. Intervention wil be applied and assesment will be done through fugl-meyer upper extremity scale, Modified Aashwarth scale,goniometry and action research arm test at zero, 3rd and 6th week.

详细描述

Informed consent was taken and patients were assessed for eligibility and patients who meet the inclusion criteria were randomized through simple random sampling into experimental and control group. Zero, 3rd and 6th week assessment was done through Action research arm test to assess upper limb performance, Goniometry to assess range of motion, Fugl-meyer upper extremity scale FMUE to assess motor functioning, sensation and joint functioning and modified ashworth scale MAS to assess spasticity. Intervention was applied for 6 weeks. The intervention in control group (n=23) was conventional treatment which includes stretching (static stretching for 20 sec) and range of motion exercises (within limit of range) . Intervention was administered one set per day (12 reps per set) four repetitions for each movement direction for 3 days a week, over a course of 6 weeks. The intervention in experimental group (n=23) was conventional treatment which includes stretching (static stretching for 20 sec) and range of motion exercises (within limit of range) with neurodynamics (Dynamic neural mobilization technique) which includes median, ulnar and radial nerve mobilization. Peripheral nerve was stretched for 20 sec with addition of dynamic movement which was performed after every 2 sec for a total of 20 sec. Neurodynamics was administered, one set per day (10 rep per set) , for 3 days a week, over a course of 6 weeks. Normality of data was checked through shapiro wilk test as sample size is \<50 and parametric or non-parametric tests were applied accordingly through SPSS version 21. Rhythmic neurodynamics accelerated the nerve conduction velocity more than the general neurodynamics. Positive effect of neurodynamics to reduce tone, increase range and improve function of stroke patients were determined in 2016. Combination of neural mobilization and Botulinum toxin-A is effective to reduce pain and increase ranges of motion.Decrease in anxiety also occurs. Botulinum toxin inhibits release of acetylcholine causing a blockade of the neuromuscular patches without affecting the antagonist muscles resulting in reduced spasticity. Neural mobilization is effective than conventional neural mobilization to increase β-waves and decrease μ-rhythms in C3 and C4 areas of cerebral cortex (primary motor areas). Neural mobilization was effective for improving range of motion of shoulder joint in all degree of freedom by reducing muscle tension and increasing extensibility of neural tissue. Neural mobilization is effective to reduce spasticity in bicep brachii muscle. Decrease in myoelectric activity is the mechanism behind reduction of tone in stroke patients.

注册库
clinicaltrials.gov
开始日期
2019年1月23日
结束日期
2019年7月31日
最后更新
6年前
研究类型
Interventional
研究设计
Parallel
性别
All

研究者

责任方
Sponsor

入排标准

入选标准

  • Modified Ashworth scale (MAS) of 1 to 3, chronic cases (6 -12 months)

排除标准

  • Modified Ashworth scale (MAS) 0 and 4, painfull upper extremity, orthopedic problem (e.g fracture)
  • In upper extremity, UMNL other than stroke,
  • Any signs of inflammation, infection or malignancy

结局指标

主要结局

Modified Ashwarth Scale

时间窗: 6th weeks

Effects of neurodynamics to reduce spasticity in uppper extremity will be assesed through Modified Ashwarth Scale changes from Baseline. Modified Ashwarth Scale is a specific scale to asses spasticity. Scoring is done from 0 (no increase in muscle tone) to 4 (affected part rigid in flexion or extension).

次要结局

  • Range of motion of elbow joint ( flexion, extension, forearm Supination , Pronation)(6th week)
  • Range of motion of Wrist joint (flexion, extension , ulnar deviation , thumb abduction )(6th Week)
  • Range of motion Shoulder Joint (Flexion, Extension, abduction, internal rotation, external rotation )(6th weeks)
  • Action research arm test (ARAT)(6th week)
  • Fugl Meyer upper extremity scale(6th weeks)

研究点 (1)

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