Oxytocin Effects on the Prosocial Learning

Not Applicable

Completed

• Conditions: Healthy
• Interventions: Drug: Oxytocin; Drug: Placebo

• Registration Number: NCT04105140
• Lead Sponsor: University of Electronic Science and Technology of China

Brief Summary

To investigate whether intranasal oxytocin (24 IU) treatment can influence prosocial learning behavior in males.

Detailed Description

In a double-blind, within-subject, placebo controlled design, investigators plan to investigate the effect of oxytocin treatment on prosocial learning. Before the self-administration, participants need to finish several questionnaires including IRI, AAS, BASBIS, SPSRQ, SES, PTM, STAI, BDI, ASQ and PNAS. They would finish the PANAS again before the scanning.

Participants are informed that they perform the reward learning task either for themselves, another (unknown) person or no one (control). In the probabilistc reward learning task, associations with two stimuli with different reward probabilities are learned via monetary feedback (reward ￥1 or no reward ￥0). After the experiment, participants need to finish the PANAS.

Study Timeline

• Study Start: 2018-01-01
• Primary Completion: 2018-08-10
• Study Completion: 2018-08-10
• Study First Submitted: 2018-09-09
• Status Verified: 2019-09
• Study First Submitted QC: 2019-09-25
• Last Update Submitted: 2019-09-25
• Study First Posted: 2019-09-26
• Last Update Posted: 2019-09-26

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 90

Inclusion Criteria

• without past or current psychiatric or neurological disorders

Exclusion Criteria

• history of head injury
• medical or psychiatric illness

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
male oxytocin group	Oxytocin	male subjects with oxytocin treatment
male placebo group	Placebo	male subjects with placebo treatment

Primary Outcome Measures

Name	Time	Method
Neural processing during feedback based on prosocial learning assessed by fMRI scanner	1 hour	fMRI BOLD indices of neural processing learning related brain regions will be compared between the treatment administrations.

Secondary Outcome Measures

Name	Time	Method
Behavioral learning performance measured by E-prime	1 hour	Learning performance will be compared between the treatment administrations by calculating the accuracy of learning.

Trial Locations

Locations (1)

School of Life Science and Technology, University of Electronic Science and Technology of China; 🇨🇳 Chengdu, Sichuan, China