Oxytocin Effects on the Prosocial Learning
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 90
- 试验地点
- 1
- 主要终点
- Neural processing during feedback based on prosocial learning assessed by fMRI scanner
研究概览
简要总结
To investigate whether intranasal oxytocin (24 IU) treatment can influence prosocial learning behavior in males.
详细描述
In a double-blind, within-subject, placebo controlled design, investigators plan to investigate the effect of oxytocin treatment on prosocial learning. Before the self-administration, participants need to finish several questionnaires including IRI, AAS, BASBIS, SPSRQ, SES, PTM, STAI, BDI, ASQ and PNAS. They would finish the PANAS again before the scanning.
Participants are informed that they perform the reward learning task either for themselves, another (unknown) person or no one (control). In the probabilistc reward learning task, associations with two stimuli with different reward probabilities are learned via monetary feedback (reward ￥1 or no reward ￥0). After the experiment, participants need to finish the PANAS.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 30 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •without past or current psychiatric or neurological disorders
排除标准
- •history of head injury
- •medical or psychiatric illness
研究组 & 干预措施
male oxytocin group
male subjects with oxytocin treatment
干预措施: Oxytocin (Drug)
male placebo group
male subjects with placebo treatment
干预措施: Placebo (Drug)
结局指标
主要结局
Neural processing during feedback based on prosocial learning assessed by fMRI scanner
时间窗: 1 hour
fMRI BOLD indices of neural processing learning related brain regions will be compared between the treatment administrations.
次要结局
- Behavioral learning performance measured by E-prime(1 hour)
研究者
Keith Kendrick
Professor
University of Electronic Science and Technology of China