Glucocorticoid production in preterm infants with or without adrenal insufficiency: A cohort study
Not Applicable
- Conditions
- adrenal insufficiency of prematurity
- Registration Number
- JPRN-UMIN000022453
- Lead Sponsor
- Maternal and Perinatal Center Tokyo Women's Medical University
- Brief Summary
The cortisol concentrations did not differ between the groups before AOP onset (P = 0.20), but the total concentrations of precursors for cortisol were higher in group P (P < 0.0001). The total concentrations of precursors in group C were inversely correlated with postmenstrual age (P < 0.01). The pattern of changes in total concentrations of precursors differed between the groups (P < 0.05).
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 27
Inclusion Criteria
Not provided
Exclusion Criteria
life-threatening morbidities, surgery, major congenital or chromosomal anomalies, symptomatic patent ductus arteriosus, sepsis, necrotizing enterocolitis, or ventricular hemorrhage higher than grade 2
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 3B-hydroxysteroid dehydrogenase activity
- Secondary Outcome Measures
Name Time Method correlation between 3B-hydroxysteroid dehydrogenase activity and corrected age