A Comparative Study of Intravenous Lignocaine, Esmolol And Magnesium Sulphate For Attenuation Of Sympathoadrenal Response To Endotracheal Intubation.
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 87
- 试验地点
- 1
- 主要终点
- Hemodynamic response to Endotracheal Intubation (HR,SBP,DBP,MAP)
研究概览
简要总结
Patients posted for elective surgeries under General Anaesthesia will be assessed for Eligibility criteria. After informed consent , patient taken into OT. Intravenous access achieved , baseline hemodynamic parameters recorded and baseline blood sample for biochemical markers taken. Randomisation into 3 groups ( Group A- given Intravenous Lignocaine 1.5mg/kg) , (Group B - given Intravenous Esmolol 1mg/kg) , ( Group C- given Intravenous Magnesium sulphate 30mg/kg) . Induction of General Anaesthesia with Propofol 2 mg/kg and fentanyl 1.5 mcg/kg , followed by vecuronium bromide 0.1mg/kg for NM blockade. Following the Endotracheal Intubation , hemodynamic monitoring at 1min , 3min ,5 min and blood sampling at 5 min post intubation is done. Statistical analysis will be applied to the data collected and conclusion will be made .
研究设计
- 研究类型
- Interventional
- 分配方式
- Computer generated randomization
- 盲法
- Not Applicable
入排标准
- 年龄范围
- 18.00 Year(s) 至 55.00 Year(s)（—）
- 性别
- All
入选标准
- •1.American Society of Anaesthesiology(ASA) Physical status I and II.
- •Elective surgical procedure.
- •Either sex.
- •Consenting adults of age 18-55 years.
排除标准
- •A known sensitivity to any study drug.
- •Pregnant females.
- •Patient with chronic Hypertension or Diabetes Mellitus.
- •Patient on beta- blocker.
- •Patient with anticipated difficult airway.
- •Patient with impaired kidney or liver function.
结局指标
主要结局
Hemodynamic response to Endotracheal Intubation (HR,SBP,DBP,MAP)
时间窗: Pre-operative | 1 minute after Endotracheal Intubation | 3 minutes after Endotracheal Intubation | 5 minutes after Endotracheal Intubation
次要结局
- Biochemical markers of stress response( Serum Norepinephrine and blood sugar)(Baseline(at arrival in OT))