To Compare which drug is better out of Injection Lignocaine , Esmolol And Magnesium Sulphate to Decrease the body’s stress response to Inserting a tube in trachea.

Not yet recruiting

• Conditions: Measurement and Monitoring, (2) ICD-10 Condition: 3||Administration,

• Registration Number: CTRI/2022/10/046496
• Lead Sponsor: ABVIMS and Dr RML Hospital

Brief Summary

Patients posted for elective surgeries under General Anaesthesia will be assessed for Eligibility criteria. After informed consent , patient taken into OT. Intravenous access achieved , baseline hemodynamic parameters recorded and baseline blood sample for biochemical markers taken. Randomisation into 3 groups ( Group A- given Intravenous Lignocaine 1.5mg/kg) , (Group B - given Intravenous Esmolol 1mg/kg) , ( Group C- given Intravenous Magnesium sulphate 30mg/kg) . Induction of General Anaesthesia with Propofol 2 mg/kg and fentanyl 1.5 mcg/kg , followed by vecuronium bromide 0.1mg/kg for NM blockade. Following the Endotracheal Intubation , hemodynamic monitoring at 1min , 3min ,5 min and blood sampling at 5 min post intubation is done. Statistical analysis will be applied to the data collected and conclusion will be made .

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2022-08-10
• Study Start: 2022-10-20

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 87

Inclusion Criteria

• 1.American Society of Anaesthesiology(ASA) Physical status I and II.
• Elective surgical procedure.
• Either sex.
• Consenting adults of age 18-55 years.

Exclusion Criteria

• A known sensitivity to any study drug.
• Pregnant females.
• Patient with chronic Hypertension or Diabetes Mellitus.
• Patient on beta- blocker.
• Patient with anticipated difficult airway.
• Patient with impaired kidney or liver function.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Hemodynamic response to Endotracheal Intubation (HR,SBP,DBP,MAP)	Pre-operative | 1 minute after Endotracheal Intubation | 3 minutes after Endotracheal Intubation | 5 minutes after Endotracheal Intubation

Secondary Outcome Measures

Name	Time	Method
Biochemical markers of stress response( Serum Norepinephrine and blood sugar)	Baseline(at arrival in OT)

Trial Locations

Locations (1)

ABVIMS and Dr. RML Hospital, New Delhi; 🇮🇳 Delhi, DELHI, India

ABVIMS and Dr. RML Hospital, New Delhi

🇮🇳Delhi, DELHI, India

Dr Vishal Dahiya

Principal investigator

9205457280

vdahiya32@gmail.com