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Clinical Trials/NCT05746195
NCT05746195
Completed
Not Applicable

Use of Text Messages to Increase Whole Grain Consumption in Colorectal Cancer

University of California, San Francisco2 sites in 1 country46 target enrollmentNovember 3, 2023

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Colon Adenocarcinoma
Sponsor
University of California, San Francisco
Enrollment
46
Locations
2
Primary Endpoint
Overall score on the Acceptability of Intervention Measure (AIM)
Status
Completed
Last Updated
3 months ago

Overview

Brief Summary

This clinical trial evaluates whether an adaptive text-message intervention is useful in helping survivors of colorectal cancers (CRC) eat more whole grain foods and less refined grain foods. Most CRC survivors don't achieve the recommended intakes of whole grains or fiber, even though there is strong evidence that a high-fiber diet rich in whole grains lowers the risk of death from CRC. Dietary interventions are a promising approach for reducing death from CRC, and text message interventions specifically are a promising tool for reaching diverse populations. This trial evaluates a text-message based dietary intervention that continuously adapts message content to be specifically tailored for the participant for increasing whole grain consumption.

Detailed Description

PRIMARY OBJECTIVE: I. Determine the intervention's feasibility and acceptability. SECONDARY OBJECTIVES: I. Estimate the effect of the intervention on the percent of grains consumed that are whole. II. Estimate the effect of the intervention on total fiber intake (grams per day \[g/d\]). EXPLORATORY OBJECTIVE: I. Assess convergence of the reinforcement learning (RL) algorithm. OUTLINE: Patients receive nutrition education materials and then receive the adaptive text message intervention for 12 weeks on study. Patients who are food insecure also receive resources for food banks, information about meal delivery programs, and support for applying for Supplemental Nutrition Assistance Program (SNAP) benefits.

Registry
clinicaltrials.gov
Start Date
November 3, 2023
End Date
November 30, 2024
Last Updated
3 months ago
Study Type
Interventional
Study Design
Single Group
Sex
All

Investigators

Responsible Party
Sponsor

Eligibility Criteria

Inclusion Criteria

  • Age \> 18 years.
  • Subject has provided informed consent.
  • Diagnosis of colon or rectal adenocarcinoma.
  • Not on active treatment at the time of screening and not expected to receive active anticancer therapy (e.g., surgery, radiation, chemotherapy) during the study period.
  • At least 6 weeks since a major surgery and fully recovered.
  • Owns a mobile phone and is willing and able to receive and send text messages.
  • Able to speak/read English or Spanish.
  • Based on a screening survey, eat grains and =\<50% of total grains are whole grains.

Exclusion Criteria

  • 1\. Does not meet any of the above inclusion criteria.

Outcomes

Primary Outcomes

Overall score on the Acceptability of Intervention Measure (AIM)

Time Frame: At 12 weeks

The AIM is a four-item measure of implementation that assesses participants perceived acceptability of the intervention. Each item response falls on a scale of 1 (Completely disagree) to 5 (Completely agree). A scaled score is calculated by averaging responses. Scale values range from 1 to 5. The intervention will be determined acceptable if the overall median score is \>= 4.

Feasibility of Intervention Measure (FIM)

Time Frame: At 12 weeks

The FIM is a four-item measure of implementation that assesses participants perceived appropriateness of the intervention. Each item response falls on a scale of 1 (Completely disagree) to 5 (Completely agree). A scaled score is calculated by averaging responses. Scale values range from 1 to 5. The intervention will be determined acceptable if the overall median score is \>= 4.

Median response rate to text messages

Time Frame: Up to 12 weeks

Participants' responses to text messages that ask for a response will be quantified using medians and interquartile range (IQR). The intervention will be determined feasible if the median response proportion to text messages that ask for a reply is \>= 70%.

Overall median score on the System Usability Scale (SUS)

Time Frame: At 12 weeks

The system usability is comprised of 10 questions assessing participants perceived usability of the intervention. Each item is scored on a scale of 1 (strongly disagree) to 5 ( strongly agree). The SUS yields a single number representing a composite measure of the overall usability of the text messaging system. To calculate the SUS score, Each item's score contribution will ultimately range from 0 to 4 (For items 1,3,5,7,and 9 the score contribution is the item score minus 1 and for items 2,4,6,8 and 10, the contribution is the item score minus 5). The sum of the scores are then multiplied by 2.5 to obtain the overall value. SUS scores have a range of 0 to 100 with a score \> 68 indicating above average usability.

Overall score on the Intervention Appropriateness Measure (IAM)

Time Frame: At 12 weeks

The IAM is a four-item measure of implementation that assesses participants perceived appropriateness of the intervention. Each item response falls on a scale of 1 (Completely disagree) to 5 (Completely agree). A scaled score is calculated by averaging responses. Scale values range from 1 to 5. The intervention will be determined acceptable if the overall median score is \>= 4.

Secondary Outcomes

  • Change in percent of grains that are whole reported on the Food Frequency Questionnaire (FFQ)(Up to 12 weeks)
  • Change in mean total daily fiber intake (g/d) reported on the Food Frequency Questionnaire (FFQ)(Up to 12 weeks)

Study Sites (2)

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