Dishabituation as a treatment for impaired awareness of hypoglycaemia in type 1 diabetes: a randomised cross over study

niversity of Dundee/NHS Tayside0 个研究点目标入组 12 人开始时间: 2017年10月25日最近更新: 2022年8月29日

适应症

试验速览

2020 Results article in https://pubmed.ncbi.nlm.nih.gov/31942669/ results (added 04/09/2020) 2020 Protocol article in https://pubmed.ncbi.nlm.nih.gov/33532608/ (added 17/08/2022)

•1. Adults =18 and = 55 years
•2. Type 1 diabetes
•3. > 5 years disease duration
•4. HbA1c < 75 mmol/l
•5. On intensive insulin therapy (CSII or MDI)
•6. Impaired awareness of hypoglycaemia (Gold score =4 or Modified Clark score=4 or DAFNE hypoglycaemia awareness rating 2 or 3)

•1. Competitive sportsman/woman
•2. History of significant heart disease
•3. Treatment with beta blockers
•4. Renal impairment (eGFR<60)
•5. History of significant lung disease – that limits exercise
•6. History of significant neurological disease – including seizures second to hypoglycaemia
•7. High risk foot disease
•8. Previous amputation of toes/foot/leg
•9. Pregnant women or breast feeding mothers
•10. Participation in HIT or equivalent in past 6 months
•11. Physical ability that may limit exercise
•12. Inability to give consent

发起方

niversity of Dundee/NHS Tayside