Measurement of Viral Load Reduction in the Oral Cavity After a Regimental Use of OC Toothpaste Products
试验速览
- 阶段
- 3 期
- 状态
- 已完成
- 入组人数
- 46
- 试验地点
- 1
- 主要终点
- Primary outcome based on reductions of viral titers in the oral cavity as determined by qRT-PCR
研究概览
简要总结
SARS COVID 2 has caused a pandemic of proportions unparalleled in the past 100 years. The virus has an uncanny ability for transmission and as such has been difficult to control. The spread of the virus has affected everything from education, business, politics and survival. While the investigators have learned a great deal in the last 9 months they still face an uncertain day to day existence. Health care workers are particularly vulnerable to transmission of this virus because of their close contact with patients. Moreover, dentists are particularly vulnerable because the virus is spread via aerosols which are generated quite easily in the dental office putting dentists and their associates at risk. The oral cavity appears to be a likely domain for viral carriage particularly since both taste and smell are hallmark effects of the virus. With these issues at hand it will be of great advantage to have a simple routine oral hygiene method in the effort to reduce the oral viral load. There is some reason to expect that oral hygiene procedures with known anti-microbial effects could have some use in our efforts to reduce or control the oral viral load. With this issue in mind investigators feel that stannous fluoride could modify the virus in such a manner as to effectively reduce the oral viral load.
详细描述
Study will measure reduction of SARS-CoV-2 levels in the oral cavity after brushing for up to an hour. Subject sampling will occur at baseline, 15 min, 30 min, and 60 min
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 64 Years(Adult)
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Enrolled subjects between the ages of 18-64 and have tested positive for Covid19.
排除标准
- 未提供
研究组 & 干预措施
Colgate Total Clean Mint
Brush with toothpaste for a minimum of 2 minutes
干预措施: Colgate Total Clean Mint (Drug)
Tom's Botanically Bright Peppermint
Brush with toothpaste for a minimum of 2 minutes
干预措施: Tom's Botanically Bright Peppermint (Drug)
结局指标
主要结局
Primary outcome based on reductions of viral titers in the oral cavity as determined by qRT-PCR
时间窗: 60 minutes after brushing
Primary outcome based on reductions of viral titers in the oral cavity as determined by qRT-PCR
次要结局
未报告次要终点
