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临床试验/NCT04864925
NCT04864925已完成3 期

Measurement of Viral Load Reduction in the Oral Cavity After a Regimental Use of OC Toothpaste Products

Colgate Palmolive1 个研究点 分布在 1 个国家目标入组 46 人开始时间: 2020年12月28日最近更新:
适应症
干预措施
相关药物

试验速览

阶段
3 期
状态
已完成
入组人数
46
试验地点
1
主要终点
Primary outcome based on reductions of viral titers in the oral cavity as determined by qRT-PCR

研究概览

简要总结

SARS COVID 2 has caused a pandemic of proportions unparalleled in the past 100 years. The virus has an uncanny ability for transmission and as such has been difficult to control. The spread of the virus has affected everything from education, business, politics and survival. While the investigators have learned a great deal in the last 9 months they still face an uncertain day to day existence. Health care workers are particularly vulnerable to transmission of this virus because of their close contact with patients. Moreover, dentists are particularly vulnerable because the virus is spread via aerosols which are generated quite easily in the dental office putting dentists and their associates at risk. The oral cavity appears to be a likely domain for viral carriage particularly since both taste and smell are hallmark effects of the virus. With these issues at hand it will be of great advantage to have a simple routine oral hygiene method in the effort to reduce the oral viral load. There is some reason to expect that oral hygiene procedures with known anti-microbial effects could have some use in our efforts to reduce or control the oral viral load. With this issue in mind investigators feel that stannous fluoride could modify the virus in such a manner as to effectively reduce the oral viral load.

详细描述

Study will measure reduction of SARS-CoV-2 levels in the oral cavity after brushing for up to an hour. Subject sampling will occur at baseline, 15 min, 30 min, and 60 min

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Prevention
盲法
Triple (Participant, Investigator, Outcomes Assessor)

入排标准

年龄范围
18 Years 至 64 Years(Adult)
性别
All
接受健康志愿者

入选标准

  • Enrolled subjects between the ages of 18-64 and have tested positive for Covid19.

排除标准

  • 未提供

研究组 & 干预措施

Colgate Total Clean Mint

Experimental

Brush with toothpaste for a minimum of 2 minutes

干预措施: Colgate Total Clean Mint (Drug)

Tom's Botanically Bright Peppermint

Active Comparator

Brush with toothpaste for a minimum of 2 minutes

干预措施: Tom's Botanically Bright Peppermint (Drug)

结局指标

主要结局

Primary outcome based on reductions of viral titers in the oral cavity as determined by qRT-PCR

时间窗: 60 minutes after brushing

Primary outcome based on reductions of viral titers in the oral cavity as determined by qRT-PCR

次要结局

未报告次要终点

研究者

申办方类型
Industry
责任方
Sponsor

研究点 (1)

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