NL-OMON32679
Recruiting
Not Applicable
Pharmacokinetics and pharmacodynamics of drugs for Nontuberculous Mycobacterial diseases in Dutch patients - PK and PD of drugs for Nontuberculous Mycobacterial diseases
niversitair Medisch Centrum Sint Radboud0 sites26 target enrollmentTBD
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- non tuberculous mycobacteria
- Sponsor
- niversitair Medisch Centrum Sint Radboud
- Enrollment
- 26
- Status
- Recruiting
- Last Updated
- last year
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Currently treated for NTM infection or recently diagnosed with NTM infection starting treatment at ULC Dekkerswald, Groesbeek, or Centre for Revalidation Beatrixoord, Haren, the Netherlands.
- •Diagnosis and treatment according to ATS criteria for NTM infections. Patients with pulmonary (eventually with extrapulmonary localizations) NTM infections are eligible.
- •Treated with at least rifampicin and ethambutol and optionally with claritromycin or azitromycin on a daily basis.
- •Age \>\=18 years.
- •Patient has been using drugs for at least two weeks when steady state concentrations of rifampicin and azithromycin is expected.
- •Informed consent has been signed.
Exclusion Criteria
- •The medical state of the patients does not allow inclusion according to the physician in attendance.
- •The patients\* clinical parameters urge immediate cessation of drugs.
- •The patient is pregnant.
- •Significant hepatic or renal dysfunction
- •Patients with cystic fibrosis, since these show deviating pharmacokinetics for many drugs.
- •Patients with HIV infection
Outcomes
Primary Outcomes
Not specified
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