A randomised controlled pilot trial of the feasibility and safety of therapy withdrawal in asymptomatic patients with a prior diagnosis of dilated cardiomyopathy & recovered cardiac function. - Therapy withdrawal in REcovered Dilated cardiomyopathy trial (TRED)

Royal Brompton & Harefield NHS Foundation Trust0 个研究点目标入组 50 人开始时间: 2016年1月19日最近更新: 2019年12月16日

适应症

试验速览

暂无简介。

•1. Diagnosis of DCM confirmed by 2 independent operators based on clinical details and previous imaging.
•2. Currently taking at least 1 of the following medications: loop diuretic, beta blocker, Angiotensin Converting Enzyme (ACE) inhibitor, Angiotensin Receptor Blocker (ARB) and Mineralocorticoid Receptor antagonist (MRA).
•3. Evidence of Left Ventricular Reverse Remodelling (LVRR) following the initial diagnosis with subsequent improvement in ejection fraction from =40% to =50% and normalisation of LV volumes on CMR (1) (or echocardiography if a contraindication to CMR exists).
•4. Without symptoms of heart failure (NYHA Class 1) (2).
•5. Plasma NTproBNP <250ng/ml.
•(1) Maceira et al. Normalized left ventricular systolic and diastolic function by steady state free precession cardiovascular magnetic resonance. JCMR 2006;8:417-426.
•(2) The Criteria Committee of the New York Heart Association. Nomenclature and Criteria for Diagnosis of Diseases of the Heart and Great Vessels. 9th ed. Boston, Mass: Little, Brown & Co; 1994:253-256.
•Are the trial subjects under 18? no
•Number of subjects for this age range: 0
•F.1.2 Adults (18-64 years) yes
•F.1.2.1 Number of subjects for this age range 25
•F.1.3 Elderly (>=65 years) yes
•F.1.3.1 Number of subjects for this age range 25

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