A Randomized Trial Evaluating Resistance Training and Dietary Supplements as Intervention for Regaining Muscle Mass Following Radiotherapy in Head and Neck Cancer Patients
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Head and Neck Neoplasms
- Sponsor
- Danish Head and Neck Cancer Group
- Enrollment
- 30
- Locations
- 2
- Primary Endpoint
- Muscle mass and muscle strength
- Status
- Completed
- Last Updated
- 9 years ago
Overview
Brief Summary
The purpose of this study is to investigate whether resistance training in combination with dietary supplementation is tolerable among head and neck cancer patients and to evaluate the possible effect on muscle mass, strength and functional capacity.
Detailed Description
Head and neck cancer patients experience a significant loss of muscle mass following radiotherapy treatment due to cachexia and dysphagia. This negatively affects muscle strength and functional capacity. Studies on healthy individuals and various groups of patients show that resistance training in combination with protein and creatine ingestion is an effective means of increasing muscle mass, strength and functional capacity. Thus the aim is to investigate the following: * is resistance training and dietary supplements tolerable among head and neck cancer patients * the effect of the intervention on muscle mass, strength and functional capacity
Investigators
Jens Overgaard
Professor, MD
Danish Head and Neck Cancer Group
Eligibility Criteria
Inclusion Criteria
- •head and neck cancer patients (localized to the larynx, pharynx and oral cavity) treated with curative radiotherapy
- •complete loss of tumor
- •WHO performance status between 0-1 and expected ability to complete the training protocol
- •No parenteral feeding
- •above the age of 18
- •written concent
Exclusion Criteria
- •other malignant diseases
- •pregnancy
- •undergoing systematic resistance training or creatin ingestion
- •Alcohol abuse
Outcomes
Primary Outcomes
Muscle mass and muscle strength
Time Frame: 13 weeks
Secondary Outcomes
- Functional capacity(13 weeks)