Cognitive Control of Language

Not Applicable

Completed

Interventions: Other: Training session
Other: First fMRI session
Other: Second fMRI session
Other: Third session of fMRI

Brief Summary: The cognitive control of speech is central to human social communication. Two frontal brain regions seem to have a critical role: 1) Broca's area (BA) and 2) the mid-cingulate cortex (MCC). Current rehabilitation strategy is clearly based on therapies promoting language performance. However, there is few evidence that rehabilitation strategies based on nonlinguistic aspects of brain function may enhance recovery. Such strategies may benefit from knowledge about the primary -nonlinguistic- function of the BA-MCC network. The aim of LANGUAGE is to identify this primary function. One hypothesis is that, in non-speaking primates, this network is involved in cognitive control of voluntary vocal/orofacial production. Specifically, whereas BA may be responsible for the high-level selection of orofacial and vocal responses during learning, the face motor representation within the MCC may be responsible for performance monitoring, a process inherently required in learning. LANGUAGE aims to test this hypothesis by determining in human the anatomo-functional organization of the BA-MCC network thanks to functional magnetic resonance imaging (fMRI).

Recruitment & Eligibility

Inclusion Criteria

Exclusion Criteria

Subjects with MRI contraindications (e.g. pacemaker, claustrophobia, metal in the body, etc...).
Subjects must be willing to be advise in case of discovery of brain abnormality.
History of known neurological or psychiatric illness
Pregnant or nursing women
Persons under guardianship, curators or any other administrative or judicial measure of deprivation of rights

Arm && Interventions

Group	Intervention	Description
Behavioral Tasks	Training session	Each subject will conduct 4 sessions, i.e. a training session and three fMRI sessions. The first session will consist in training the subject to carry out the different behavioral tasks that he will then have to perform during the sessions of fMRI.
Behavioral Tasks	First fMRI session	Each subject will conduct 4 sessions, i.e. a training session and three fMRI sessions. The first session will consist in training the subject to carry out the different behavioral tasks that he will then have to perform during the sessions of fMRI.
Behavioral Tasks	Second fMRI session	Each subject will conduct 4 sessions, i.e. a training session and three fMRI sessions. The first session will consist in training the subject to carry out the different behavioral tasks that he will then have to perform during the sessions of fMRI.
Behavioral Tasks	Third session of fMRI	Each subject will conduct 4 sessions, i.e. a training session and three fMRI sessions. The first session will consist in training the subject to carry out the different behavioral tasks that he will then have to perform during the sessions of fMRI.

Primary Outcome Measures

Name	Time	Method
fMRI data	3 years	BOLD signal will be analyzed in relation to the events of the task. Images must be not too much distorted to allow data analysis. As such, if a subject moved too much (translation\>10mm; rotation\>5°) the corresponding data will be excluded from the analysis.
Behavioral data: performance in the task	3 years	Performance in the task will be assessed. If performance in the task is \<80%, subjects will be excluded in the final analysis

Secondary Outcome Measures

Name	Time	Method

Receive instant email notifications about changes in this clinical trial

Receive instant email notifications about changes in this clinical trial