Is Tuberculin Skin Testing Effective in Screening for Latent TB in Elderly Residents of Nursing Homes? Comparison With a New IFN-y Based Assay
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 135
- 试验地点
- 1
- 主要终点
- detection of latent TB
研究概览
简要总结
In face of the increased rates of tuberculosis in residents of long term care facilities, annual screening for latent tuberculosis is recommended. Tuberculin skin testing using purified protein derivative (PPD) is used for this purpose. Sensitivity of the PPD testing is, however, dependent on a normal T cell function. It is now evident that the immune system undergoes age-associated alteration known as immune senescence. The depressed T-cell responses may clinically manifest as attenuated delayed-type hypersensitivity. This attenuated reaction may affect the sensitivity of the PPD in detection of latent TB in the elderly.
This prospective study will examine the utility of interferon-gamma (IFN-γ) based assay, T-SPOT.TB, for detection of latent tuberculosis in nursing home patients who are 65 years of age or older.
研究设计
- 研究类型
- Observational
- 时间视角
- Prospective
入排标准
- 年龄范围
- 65 Years 至 —（Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •65 years of age and older
- •No ulcerating or blistering skin disorder
- •No previous history of adverse reaction to PPD testing
- •No blood transfusion within 6 weeks prior to enrollment
- •If the participant had a PPD placed and read by a public health department representative within the last 6 months, repeat PPD will not be done, but the person may participate in the study
- •Participant may have been Bacille de Calmette et Guerin (BCG)-vaccinated
排除标准
- •Less than 65 years
- •Not a resident of a long term care facility
- •Diagnosis of Tuberculosis
- •blood transfusion within 6 weeks of enrollment
- •Prior diagnosis of immune deficiency
结局指标
主要结局
detection of latent TB
时间窗: 2 years
次要结局
未报告次要终点
研究者
Donna Seminara
Program Director, Geriatric Medicine
Northwell Health