Cough Determinants in Mechanically Ventilated Patients

Not Applicable

Completed

• Conditions: Mechanical Ventilation

• Registration Number: NCT01564745
• Lead Sponsor: University Hospital, Caen

Brief Summary

In our knowledge there is only few data about the cough determinants in mechanically ventilated patients. However some failure of extubation is due to inefficiency cough. In order to determine some determinants of cough, the investigators propose to evaluate systematically different physiological parameters before and after extubation.

Detailed Description

In order to evaluate, and identify the cough determinants, the investigators propose a physiological evaluation for each patients who were intubated and mechanically ventilated during at least 72 hours. Indeed inefficacy of cough after extubation is one of the main reason of extubation failure. However there is no any mean to evaluate it simply now.

Study Timeline

• Study Start: 2012-03
• Study First Submitted: 2012-03-25
• Study First Submitted QC: 2012-03-27
• Study First Posted: 2012-03-28
• Status Verified: 2014-02
• Primary Completion: 2015-12
• Study Completion: 2015-12
• Last Update Submitted: 2019-04-18
• Last Update Posted: 2019-04-22

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 180

Inclusion Criteria

• Patients mechanically ventilated since 72h
• Age > 18 years
• Hospitalized in Intensive care Unit
• In weaning phase - with the classically criteria to be extubated
• Patients who passed the weaning test (T tube test or other)

Exclusion Criteria

• Hemodynamic instability
• Absence of consent
• No cooperation of the patient
• Hemodynamic instability
• pH < 7,30
• Severe hypoxemia

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
Interest of systematically cough evaluation before extubation	2 days after extubation	All the patients enrolled have a physiological evaluation before and after extubation. After extubation the evaluation will be done respectively at D0, D1, D3 and D5. The first endpoint is the success of extubation which is evaluated à D2.

Secondary Outcome Measures

Name	Time	Method
Correlation between success of extubation and respiratory parameters	2 days after extubation

Trial Locations

Locations (2)

University Hospital, Caen; 🇫🇷 Caen, France

University Hospital, Garches; 🇫🇷 Garches, France