Physical Activity for a Long and Healthy Life - Project FINE
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 64
- 试验地点
- 2
- 主要终点
- Change from baseline in insulin sensitivity at 12 weeks
研究概览
简要总结
The aim of the study is to 1) delineate the molecular mechanisms behind the large variation in insulin sensitivity among apparently healthy subjects and to 2) establish the dose-response relationship between physical training and a) metabolic health, b) appetite and c) cultural health.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 40 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Healthy according to interview
- •Caucasian
- •Sedentary, Vo2max < 45 ml/kg/min
- •BMI 25-30 kg/m2
- •Fat percentage 25% <
- •Weight stable (+/- 2 kg within past 6 months)
排除标准
- •First degree relatives with type 2 diabetes
- •Hemoglobin concentration < 8 mmol/l
- •Fasting plasma glucose 6.1 mmol/l <
- •Blood pressure 140/90 mmHg <
- •Regular intake of medicine
研究组 & 干预措施
600 kcal/day
Exercise combusting 600 kcal/day, 7 days/week for 12 weeks.
干预措施: Exercise (Behavioral)
300 kcal/day
Exercise combusting 300 kcal/day, 7 days/week for 12 weeks.
干预措施: Exercise (Behavioral)
Sedentary
Continued sedentary living.
结局指标
主要结局
Change from baseline in insulin sensitivity at 12 weeks
时间窗: At baseline and 12 weeks
As measured by a hyperinsulinemic, isoglycemic clamp combined with skeletal muscle and adipose tissue biopsies as well as low-dose PET/CT.
次要结局
- Change from baseline in appetite at 12 weeks(At baseline and 12 weeks)
- Motivational factors for exercise(During and for up to 1½ year after the intervention)
- Diameter of t-tubuli in skeletal muscle(At baseline)
- Change from baseline in body composition af 2, 6 and 12 weeks(At baseline, 2, 6 and 12 weeks)
研究者
Bente Merete Stallknecht
Associate professor
University of Copenhagen