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临床试验/NCT02402075
NCT02402075Unknown不适用

Spinal Motor Evoked Potentials During Neurosurgical Procedures Within the Central Region

Heinrich-Heine University, Duesseldorf2 个研究点 分布在 1 个国家目标入组 40 人开始时间: 2014年1月最近更新:
适应症

试验速览

阶段
不适用
发起方
入组人数
40
试验地点
2
主要终点
Clinical motor status according to the MRC scheme

研究概览

简要总结

During neurosurgical resection of brain tumors within brain areas for motor control, it is important to monitor motor function. For this muscle motor evoked potentials are used. Those are elicited by transcranial and direct cortical stimulation. Motor responses are recorded from muscles. In neurosurgical procedures for spinal cord tumors, the same methods are used, but additionally motor activity is recorded from the spinal cord. This is called spinal motor evoked potentials. It is known that the relation between spinal and muscle motor evoked potentials helps to extent the resection of spinal cord tumors. This study implements the spinal motor evoked potential into brain tumor surgery and analyses the relationship between spinal and muscle motor evoked potentials. With this, detection of injury to the brain area for motor control might be discovered earlier and thus tumor resection can be performed safely.

研究设计

研究类型
Observational
观察模型
Case Only
时间视角
Prospective

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • > 18 years
  • tumor location adjacent to the motor cortex and corticospinal tract

排除标准

  • neurological degenerative diseases
  • neurological immunological diseases
  • drug abuse
  • implanted medical devices such as cardiac pacemaker
  • spine deformation

结局指标

主要结局

Clinical motor status according to the MRC scheme

时间窗: 6 months

clinical motor status according to the MRC scheme

D-wave measurement

时间窗: 24 hours

numeric assessment, amplitude and latency of D-wave

次要结局

未报告次要终点

研究者

发起方
Heinrich-Heine University, Duesseldorf
申办方类型
Other
责任方
Principal Investigator
主要研究者

Andrea Szelenyi

Professor

Heinrich-Heine University, Duesseldorf

研究点 (2)

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