Hemodynamic Cardiac Profiler for Assessment of Acute Hemodynamic Changes in Heart Failure Patients Undergoing Cardiac Resynchronization Therapy
Completed
- Conditions
- Chronic Heart Failure10019280
- Registration Number
- NL-OMON55084
- Lead Sponsor
- Vrije Universiteit Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 10
Inclusion Criteria
Patients need to fulfil the 2013 guideline of the European Society of
Cardiology criteria for cardiac pacing and cardiac resynchronisation therapy
upon receiving a CRT.
Exclusion Criteria
Age <18
Frequent extrasystole (more than 10%)
Artificial aortic valve or aortic stenosis
LV volume > 300 ml
Other implantable devices than CRT/PM/ICD in the upper body
Structural anatomical / congenital cardiac *deviations*
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Volume-time curves obtained during various pacing configurations will be<br /><br>compared between the non-invasive method (HCP) and the invasive method<br /><br>(conductance catheter). </p><br>
- Secondary Outcome Measures
Name Time Method <p>1. Evaluate derivatives of volume-time curves (i.e. stroke volume, max volume,<br /><br>min volume, 1/3 FFR) and compare these derivatives between different pacing<br /><br>settings and between the HCP volume-time curve and conductance catheter<br /><br>volume-time curve.<br /><br>2. Assessment of pressure data during different pacing settings and comparison<br /><br>between the invasive pressure measurements (conductance catheter) and the<br /><br>non-invasive pressure measurements (Nexfin)<br /><br>3. Reconstruction of pressure-volume (PV) loops with Nexfin and HCP data and<br /><br>compare these PV- loops with PV-loops obtained using the conductance catheter.</p><br>
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms underlie acute hemodynamic changes in heart failure patients post-cardiac resynchronization therapy?
How does the Hemodynamic Cardiac Profiler compare to standard-of-care assessments in predicting CRT outcomes for chronic heart failure patients?
Which biomarkers are associated with improved response to cardiac resynchronization therapy in chronic heart failure subtypes?
What adverse events are commonly observed during cardiac resynchronization therapy in chronic heart failure patients and how are they managed?
Are there combination approaches involving the Hemodynamic Cardiac Profiler and other interventions like ICDs or beta-blockers in heart failure management?