Continuous Versus Intermittent Nebulization Therapy in Acute Asthma Exacerbation at Emergency Department

Not Applicable

Not yet recruiting

• Conditions: Asthma Exacerbation; Nebulization; Emergency Department

• Registration Number: NCT06291740
• Lead Sponsor: Thammasat University

Brief Summary

The goal of this clinical is to compare treatment outcomes between continuous nebulization and intermittent therapy in the management of acute exacerbation of asthma in the emergency department(ED). Participants will random assign to either continuous or intermittent nebulization. In the continuous group, patients receive budesonide, fenoterol, ipratropium bromide, and normal saline continuously for an hour. In the intermittent group, the same medications are administer every 20 minutes for an hour. Measurements include symptom severity, respiratory rate, oxygen saturation, and pulmonary function tests. Primary endpoints are ED stay length, hospital admission, and ED revisit within 48 hours post-discharge. Adverse events are documented.

Detailed Description

Not available

Study Timeline

• Status Verified: 2024-02
• Study First Submitted: 2024-02-19
• Study First Submitted QC: 2024-02-26
• Last Update Submitted: 2024-02-26
• Study First Posted: 2024-03-04
• Last Update Posted: 2024-03-04
• Study Start: 2024-04
• Primary Completion: 2025-04
• Study Completion: 2025-05

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• asthma exacerbation

Exclusion Criteria

• life-threatening conditions requiring intubation
• allergy to steroid or its components
• patient under investigation of Corona Virus Disease, 2019 (COVID-19)
• pulmonary tuberculosis
• unable to cooperate for pulmonary function testing

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Length of ED stay	through study completion, an average of 1 year	duration of ED management

Secondary Outcome Measures

Name	Time	Method
pulmonary function test	through study completion, an average of 1 year	Forced Expiratory Volume in one second(FEV1), Peak Expiratory Flow(PEF)