Brain Vascular and Neural Function Linked to Balance Across the Adult Lifespan
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 102
- 试验地点
- 1
- 主要终点
- Kinetic center of pressure rate of rise post-balance perturbation, assessed biomechanically.
研究概览
简要总结
This is a single-arm, two-visit, non-randomized, cross sectional study identified as an intervention due to the use of a single bout of aerobic exercise to assess cerebrovascular function under the NIH rules. This study is not masked and its primary purpose is to develop a basic science understanding of the relationship between cerebrovascular health and balance control with aging. This study will involve 102 individuals classified as younger adults, middle-aged adults, and older adults who are neurotypical and cognitively normal. The primary outcome from a clinical trials perspective will be cerebrovascular response to a bout of aerobic exercise (i.e. change in cerebral blood flow with the performance of aerobic exercise on a recumbent stepper exercise machine). Non-interventional outcomes will be EEG measures of cortical activity and biomechanical kinetic and kinematic data recorded during standing balance reactions, as well as biological blood samples for genomic analysis.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 21 Years 至 95 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age within the following 3 group age ranges, 21-30yo; middle-aged: 40-55yo; older: 65-95yo adults
- •the absence of major orthopedic disability
- •cognitively normal (MoCA score ≥ 26/30 in older adult group)
- •vision that is 20/40 or better with or without corrective lenses, (5) the ability to consent and communicate with researchers
- •English speaking
- •ability to stand for 3 minutes and walk 10 meters with or without an assistive device and without the assistance of another person.
排除标准
- •insulin-dependent diabetes
- •peripheral neuropathy
- •myocardial infarction or symptoms of coronary artery disease within 2 years
- •congestive heart failure or class IV heart failure
- •any significant sensory impairment affecting balance or cognition; visual, vestibular, or auditory impairments.
研究组 & 干预措施
Experimental group
Healthy participants in 3 age groups
干预措施: aerobic exercise (Behavioral)
结局指标
主要结局
Kinetic center of pressure rate of rise post-balance perturbation, assessed biomechanically.
时间窗: 1 week
Recordings from 64-channels of EEG electrodes, kinetic, and kinematic biomechanical data during standing balance reactions will be collected.
Prefrontal-M1 coherence an S1-M1 coherence post-balance perturbation, assessed using EEG
时间窗: 1 week
Recordings from 64-channels of EEG electrodes, kinetic, and kinematic biomechanical data during standing balance reactions will be collected.
cerebral blood flow velocity assessed using transcranial Doppler ultrasound
时间窗: 1 week
Includes recordings from transcranial Doppler ultrasound of cerebral blood flow (CBF) velocity performed at the first session during rest, sit-to-stand, transfer, and single bout of aerobic exercise.
次要结局
未报告次要终点