跳至主要内容
临床试验/CTRI/2024/03/064931
CTRI/2024/03/064931招募中不适用

Correlation between Perfusion Index and Perioperative body temperature – A Prospective observational study.

Internal Fluid Research Grant1 个研究点 分布在 1 个国家目标入组 147 人开始时间: 2024年4月5日最近更新:

试验速览

阶段
不适用
状态
招募中
发起方
入组人数
147
试验地点
1
主要终点
Perfusion index is measured by pulse oximetry, core body temperature is measured preoperatively by tympanic thermometer and intraoperatively by rectal temperature probe. Perfusion index and Core body temperature are correlated.

研究概览

简要总结

Hypothermia is defined by a low core body temperature less than 35˚C with more conservative perioperative thresholds of 36˚C. It is estimated that 50 – 90% of patients experience hypothermia during surgery. Perioperative hypothermia affects various organ systems and alter several physiological functions. These include, sympathetic nervous system activation, impaired platelet function and coagulation cascade, postoperative shivering, blunted ventilatory response to carbon dioxide, systemic and pulmonary vasoconstriction and increased arterial blood pressure, variations in serum potassium levels, impaired neutrophils and macrophages and altering the pharmacokinetic of drugs. It may lead to increased intraoperative blood loss and transfusion, surgical site infections, cardiac events, reduced clearance of drugs and prolonged action of neuromuscular blockers, increased need for mechanical ventilation and longer duration of hospital stay. These adverse effects can be minimized by prevention, treatment and increased awareness of the problems due to hypothermia. Pulse oximetry is simple, continuous, noninvasive monitor which displays peripheral oxygen saturation and heart rate using plethysmography technology. Peripheral perfusion index (PPI) is another variable measured by pulse oximetry, which is the ratio of pulsatile flow to the non-pulsatile flow of blood in the peripheral circulation. Its normal value ranges from 0.02% (weak pulse) to 20% (strong pulse). Lower values indicate vasoconstriction and higher values indicate vasodilation. It is affected by two main determinants: cardiac output and balance between sympathetic and parasympathetic nervous systems(5). Redistribution hypothermia is the main cause of potential perioperative hypothermia. It is due to vasodilation, impaired function of hypothalamus and limited body’s ability to cause vasoconstriction, mediated by general anesthesia. Changes in PPI are noted due to vasodilation and body temperature redistribution in association with general anesthesia. Hence, the aim of our study is to identify the relationship between perfusion index and core body temperature and its role in predicting perioperative hypothermia.

研究设计

研究类型
Observational

入排标准

年龄范围
18.00 Year(s) 至 70.00 Year(s)(—)
性别
All

入选标准

  • Patients in the age group 18 – 70 years undergoing elective minimally invasive abdominal surgeries 2) Patients belonging to ASA Criteria 1 and 2.

排除标准

  • body mass index (BMI) less than 20 or more than 30 2) Age less than 19 years or more than 70 years 3) American Society of Anaesthesiologists physical status (ASA-PS) score more than or equal to 3 4) Patients with peripheral vascular disease or vasculitis 5) Baseline temperature less than 36 C 6) Surgeries which get converted to open abdominal surgeries 7) Patients requiring ionotropic supports.

结局指标

主要结局

Perfusion index is measured by pulse oximetry, core body temperature is measured preoperatively by tympanic thermometer and intraoperatively by rectal temperature probe. Perfusion index and Core body temperature are correlated.

时间窗: During Induction and Maintenance of anesthesia

次要结局

  • To determine the cut off value of perfusion index before induction and ratio of PI(variation at 30 mins after induction which can predict intraoperative redistributive)

研究者

发起方
Internal Fluid Research Grant
申办方类型
Private medical college
责任方
Principal Investigator
主要研究者

Dr Abirami M

Department of Anesthesia

研究点 (1)

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