Metabolism of curcumin in healthy volunteers
- Conditions
- Bioavailability and metabolisme of curcumin100179901006291510047066
- Registration Number
- NL-OMON48906
- Lead Sponsor
- Academisch Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 9
* Healthy male, age * 18 years
* Able to give written informed consent
* Willing to follow the dietary regimens
* Able to complete the entire study
* Major illness in the past 3 months
* Gastrointestinal disease
* History of cholecystectomy or other bile duct abnormalities
* Metabolic or endocrine diseases
* Drug abuse or alcoholism (>3 units of alcohol per day)
* Use of prescription or non-prescription drugs and herbal or dietary
supplements within 30 days prior to the first administration of curcumin
supplement. With the exclusion of (non)prescription drugs used for their local
effect and thus have no influence on the kinetics of curcumin.
* Use of tobacco products
* High usage of curcumin and black pepper in daily food/beverages
* Known intolerance for curcumin or black pepper
* Participation in another clinical trial in the 3 months prior to the start of
the study.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Kinetic parameters of curcumin: AUC, clearance, volume of distribution,<br /><br>elimination half-life and possible Cmax and Tmax concentrations. </p><br>
- Secondary Outcome Measures
Name Time Method <p>Kinetic parameters of curcumin and piperine of each of the 5 products.<br /><br>Influence of curcumin and piperine on different biochemical parameters.</p><br>