PAS for Lower Extremity Rehabilitation in Tetraplegic Patients

Not Applicable

Completed

• Conditions: Spinal Cord Diseases; Spinal Cord Injuries

• Registration Number: NCT03459885
• Lead Sponsor: Helsinki University Central Hospital

Brief Summary

The investigators have recently shown in incomplete SCI patients that long-term paired associative stimulation is capable of restoring voluntary control over some paralyzed muscles and enhancing motor output in the weak muscles (1,2). In this study, the investigators will administer long-term paired associative stimulation to patients with incomplete cervical level SCI and investigate its effectiveness for lower extremity rehabilitation.

Detailed Description

Not available

Study Timeline

• Study Start: 2018-02-28
• Study First Submitted: 2018-03-03
• Study First Submitted QC: 2018-03-03
• Study First Posted: 2018-03-09
• Primary Completion: 2019-06-28
• Study Completion: 2019-06-28
• Status Verified: 2025-05
• Last Update Submitted: 2025-05-12
• Last Update Posted: 2025-05-13

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 5

Inclusion Criteria

• cervical incomplete SCI

Exclusion Criteria

• epilepsy
• metal inclusion in the head area
• pacemaker
• hearing device
• high intracranial pressure

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
Daniels and Worthingham's Muscle Testing	1 month after the last stimulation session	leg muscles are evaluated on 0-5 scale

Trial Locations

Locations (1)

BioMag laboratory, Helsinki University Central Hospital; 🇫🇮 Helsinki, Uusimaa, Finland