Stress-induced Cortisol Clouds the Gut Feeling in Decision-making: A Randomized Controlled Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 116
- 试验地点
- 1
- 主要终点
- Decision-making as assessed by the Iowa Gambling Task (probability of drawing from the risky decks vs safe decks)
研究概览
简要总结
The goal of this study is to learn how acute psychosocial stress influences decision-making in healthy young adults. It will also examine whether cortisol reactivity, a biological stress response, changes the influence of physiological emotional signals on decision-making (i.e., the gut feeling indicating risks).
The main questions it aims to answer are:
- Does exposure to an acute psychosocial stressor affect the development of physiological emotional signals during decision-making?
- Does cortisol reactivity moderate the relationship between physiological emotional signals and decision-making?
- Are there sex differences in these relationships?
Researchers will compare participants exposed to a standardized psychosocial stress procedure, with participants exposed to a non-stressful control condition.
Participants will:
- Be randomly assigned to either a psychosocial stress condition or a control condition.
- Complete a gambling decision-making task following the experimental manipulation.
- Provide multiple saliva samples and subjective stress ratings throughout the session to assess stress reactivity.
- Undergo continuous electrodermal activity recording during the decision-making task to measure physiological emotional signals.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Adult aged 18-35 years old.
排除标准
- •Current or past psychiatric/neurodevelopmental disorders
- •Physical illness
- •Medication use (except hormonal contraception)
- •Alcohol consumption exceeding Health Canada guidelines (>10 drinks/week for women, >15 for men)
- •Smoking more than 7 cigarettes/day.
研究组 & 干预措施
Control condition
In the control condition, participants read magazines for an equivalent period of time to the Stress condition.
Stress condition
Participants completed a slightly modified version of the Trier Social Stress Task (TSST), a validated psychosocial stress induction protocol. The protocol involved a 10-minute anticipation period followed by a 10-minute test phase: a 5-minute mock job interview and a 5-minute surprise mental arithmetic task. During the test phase, participants stood in front of a one-way mirror ("Panel-out" version) and were told they were being observed by behavioral analysts and recorded via camera, although no recording took place and the analysts were lab confederates.
干预措施: Trier Social Stress Test (Other)
结局指标
主要结局
Decision-making as assessed by the Iowa Gambling Task (probability of drawing from the risky decks vs safe decks)
时间窗: Immediately after completing the experimental condition (Stress or control condition)
Decision-making was assessed using the Iowa Gambling Task. In this task, participants need to draw 100 cards among 4 decks offering different win-loss contingencies. Some card decks are risky (large gains and losses), whereas some are safe (small gains and losses). The dependent variable was a binary variable indicating whether the participant drew a card from the risky (coded as 1) or the safe decks (coded as 0).
次要结局
- Difference in cortisol levels between the two conditions.(Baseline (just before the experimental condition is conducted), 10, 20, 50, 60, 70 minutes after the beginning of the experimental condition.)
研究者
Marie-France Marin
Core researcher
Centre de Recherche de l'Institut Universitaire en santé Mentale de Montréal