An International Survey on Aminoglycoside Practices in Critically Ill Patients: AMINO III Survey
- Conditions
- Underdosing of AminoglycosidesCritical Illness
- Interventions
- Other: Observational study, no intervention
- Registration Number
- NCT02850029
- Lead Sponsor
- Centre Hospitalier Universitaire de Nīmes
- Brief Summary
This is an international observational cohort study on current aminoglycoside practices in intensive care units. Clinical and demographic data, dosing and therapeutic drug monitoring data will be collected during the first week of aminoglycoside (tobramycin, amikacin or gentamicin) administration in different countries over a year. A minimum of ten consecutive patients will be enrolled at each site.
- Detailed Description
Aminoglycosides are commonly used antibiotics for difficult to treat infections. However, aminoglycoside administration varies widely among countries. The aim of this multicenter observational study is to provide up-to-date and comprehensive descriptive data on current aminoglycoside (tobramycin, amikacin or gentamicin) use in a large cohort of critically ill patients in different countries. The benefits expected from this study are a better understanding of worldwide aminoglycoside prescription variability in critically ill patients and to determine the risk factors of inadequate aminoglycoside dosing regimens.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 964
- Age ≥ 18 years old
- Intensive care unit patients
- Receiving aminoglycoside therapy for a sepsis according to the Third International Consensus Definitions for Sepsis and Septic Shock
- Aged < 18 years of age
- Previous inclusion in the study
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description critically ill patients Observational study, no intervention Critically ill patients admitted in intensive care units and receiving one of the following aminoglycosides: gentamicin, tobramycin and amikacin as part of their usual care.
- Primary Outcome Measures
Name Time Method Aminoglycoside current practices descriptive data in intensive care units Seven first days of aminoglycoside therapy
- Secondary Outcome Measures
Name Time Method Aminoglycoside therapy duration Seven first days of aminoglycoside therapy Aminoglycoside therapeutic drug monitoring Seven first days of aminoglycoside therapy Aminoglycoside dosing regimens Seven first days of aminoglycoside therapy
Trial Locations
- Locations (83)
CHU Nice- Hopital Pasteur
🇫🇷Nice, France
Chu Lyon- Lyon Sud
🇫🇷Lyon, France
APHP- Bichat
🇫🇷Paris, France
Centre Hospitalier Aix-En-Provence
🇫🇷Aix-en-provence, France
Hospital Barros Luco Trudeau
🇨🇱Santiago, Chile
Frankston Hospital Victoria
🇦🇺Frankston, Australia
Sunshine Coast hospital
🇦🇺Sunshine Coast, Australia
Chu Amiens
🇫🇷Amiens, France
Centre Hospitalier Aurillac
🇫🇷Aurillac, France
Chru Brest
🇫🇷Brest, France
Royal Brisbane Women's Hospital
🇦🇺Brisbane, Queensland, Australia
Hospital Base de Valvidia
🇨🇱Valdivia, Region DE LOS RIOS, Chile
Salvador Santiago Hospital
🇨🇱Santiago, Chile
Chu Lyon- Hopital La Croix Rousse
🇫🇷Lyon, France
Centre Hospitalier La Rochelle-Hopital Saint Louis
🇫🇷La Rochelle, France
Centre Hospitalier du Mans
🇫🇷Le Mans, France
AP-HM - Hopital Nord
🇫🇷Marseille, France
Chru Nancy -Hopital de Brabois
🇫🇷Nancy, France
Royal Brisbane and Women's Hospital
🇦🇺Brisbane, Australia
APHM La timone
🇫🇷Marseille, Paca, France
Centre Hospitalier Avignon
🇫🇷Avignon, France
Chru Besancon
🇫🇷Besançon, France
Centre Hospitalier Bourg En Bresse
🇫🇷Bourg En Bresse, France
CHU CAEN
🇫🇷Caen, France
Centre Hospitalier Charleville-Mezieres
🇫🇷Charleville-mezieres, France
Chu Grenoble
🇫🇷Grenoble, France
Aphm- La Conception
🇫🇷Marseille, France
CHU MONTPELLIER-Hopital Lapeyronnie
🇫🇷Montpellier, France
CHU Nice-Hopital L'Archet
🇫🇷Nice, France
CHU REIMS- Hopital Robert Debré
🇫🇷Reims, France
CHU ROUEN- Hopital Nicolle
🇫🇷Rouen, France
AP-HP - Paris St Louis
🇫🇷Paris, France
Chu Brest- Hopital Cavale
🇫🇷Brest, France
Centre Hospitalier de Compiegne
🇫🇷Compiegne, France
Centre Hospitalier Sambre-Avesnois
🇫🇷Maubeuge, France
Centre Hospitalier de Montauban
🇫🇷Montauban, France
Centre Hospitalier de MORLAIX
🇫🇷Morlaix, France
Aphp - Pitie Salpetriere
🇫🇷Paris, France
APHP-Hopital Georges Pompidou
🇫🇷Paris, France
Chu Clermont-Ferrand
🇫🇷Clermont-ferrand, France
CHU MONTPELLIER-Hopital St Eloi
🇫🇷Montpellier, France
Chu Nantes- Hopital Hotel Dieu
🇫🇷Nantes, France
AP-HP - Hopital Paris St Antoine
🇫🇷Paris, France
CHU NANTES- hôpital Nord Laennec
🇫🇷Nantes, France
Centre Universitaire de Nimes
🇫🇷Nimes, France
Chu Poitiers
🇫🇷Poitiers, France
Centre Hospitalier de Roanne
🇫🇷Roanne, France
APHP- Descartes
🇫🇷Paris, France
AP-HP - Bicetre
🇫🇷Paris, France
Sandwell and west Birmingham hospital
🇬🇧Birmingham, United Kingdom
Chu Bordeaux
🇫🇷Bordeaux, France
Chu Angers
🇫🇷Angers, France
Toowoomba Hospital
🇦🇺Toowoomba, Australia
Centre Hospitalier D'Ales
🇫🇷Ales, France
CHI Robert Ballanger
🇫🇷Aulnay-sous-Bois, France
Centre Hospitalier Arles
🇫🇷Arles, France
Centre Hospitalier de BOULOGNE SUR MER
🇫🇷Boulogne sur mer, France
Centre Hospitalier de PAU
🇫🇷PAU, France
Centre Hospitalier de Salon de Provence
🇫🇷Salon de Provence, France
CHU SAINT-ETIENNE - Hopital Nord
🇫🇷Saint-etienne, France
Centre Hospitalier de Toulon, Hopital Sainte Musse
🇫🇷Toulon, France
Centre Hospitalier Valence
🇫🇷Valence, France
Centre Hospitalier de Valenciennes
🇫🇷Valenciennes, France
CHU TOULOUSE- Hopital Rangueil
🇫🇷Toulouse, France
University Critical Care Department Aghioi Anargyroi Hospital
🇬🇷Athens, Greece
Guy'S and St Thomas'
🇬🇧London, United Kingdom
University Hospital Birmingham
🇬🇧Birmingham, United Kingdom
Salford royal
🇬🇧Manchester, United Kingdom
University Hospital of South Manchester
🇬🇧Manchester, United Kingdom
St Helens and Knowsley Hospitals
🇬🇧Prescot, United Kingdom
Oxford Radcliffe Hospitals
🇬🇧Oxford, United Kingdom
Sheffield Teaching Hospitals
🇬🇧Sheffield, United Kingdom
Southampton University Hospitals
🇬🇧Southampton, United Kingdom
Aphp- Pitie Salpetriere
🇫🇷Paris, France
CHU RENNES - Hopital Pontchaillou
🇫🇷Rennes, France
Centre Hospitalier de Rodez
🇫🇷Rodez, France
Centre Hospitalier Sainte Catherine
🇫🇷Saverne, France
CHU La Reunion-Hopital Felix Guyon
🇫🇷Saint Denis, France
University Hospital of loannina
🇬🇷Ioánnina, Greece
Naval and Veterans Hospital of Athens
🇬🇷Athens, Greece
G. Gennimatas General Hospital
🇬🇷Thessaloníki, Greece
Hospital CU Chile
🇨🇱Santiago, Chile
Athens Hippocratio Hospital
🇬🇷Athens, Greece