An International Survey on Aminoglycoside Practices in Critically Ill Patients: AMINO III Survey
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 964
- 试验地点
- 83
- 主要终点
- Aminoglycoside current practices descriptive data in intensive care units
研究概览
简要总结
This is an international observational cohort study on current aminoglycoside practices in intensive care units. Clinical and demographic data, dosing and therapeutic drug monitoring data will be collected during the first week of aminoglycoside (tobramycin, amikacin or gentamicin) administration in different countries over a year. A minimum of ten consecutive patients will be enrolled at each site.
详细描述
Aminoglycosides are commonly used antibiotics for difficult to treat infections. However, aminoglycoside administration varies widely among countries. The aim of this multicenter observational study is to provide up-to-date and comprehensive descriptive data on current aminoglycoside (tobramycin, amikacin or gentamicin) use in a large cohort of critically ill patients in different countries. The benefits expected from this study are a better understanding of worldwide aminoglycoside prescription variability in critically ill patients and to determine the risk factors of inadequate aminoglycoside dosing regimens.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age ≥ 18 years old
- •Intensive care unit patients
- •Receiving aminoglycoside therapy for a sepsis according to the Third International Consensus Definitions for Sepsis and Septic Shock
排除标准
- •Aged < 18 years of age
- •Previous inclusion in the study
结局指标
主要结局
Aminoglycoside current practices descriptive data in intensive care units
时间窗: Seven first days of aminoglycoside therapy
次要结局
- Aminoglycoside therapy duration(Seven first days of aminoglycoside therapy)
- Aminoglycoside therapeutic drug monitoring(Seven first days of aminoglycoside therapy)
- Aminoglycoside dosing regimens(Seven first days of aminoglycoside therapy)