Effect of Two Different Doses of Neostigmine on the Gastric Residual Volume and Aspiration in Critically Ill Patients
- Registration Number
- NCT06687187
- Lead Sponsor
- Zulekha Hospitals
- Brief Summary
A study comparing the effect of two doses of neostigmine on the gastric residual volume in critically ill patients on enteral feeding.
- Detailed Description
Participants were categorized into three groups: Group I and Group II received neostigmine 1 mg and 2 mg, respectively, and a control group received 10 ml of normal saline. All participants received an intravenous administration of 10 mg of metoclopramide. GRV was measured every 3 hours before enteral feeding. aspiration through nasogastric (NG) or orogastric (OG) tubes was done before the next due bolus of feeding.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 3
Inclusion Criteria
- patients with a GRV >120ml
- a normal heart rateExclusion Criteria
- absence of comorbidities such as diabetes and renal failure. exclusion Criteria:
- Patients exhibiting new-onset arrhythmias or heart block
- hypotension (systolic blood pressure less than 60 mmHg)
- experiencing active gastrointestinal bleeding or receiving prokinetic medications 8-12 hours before the intervention
- patients with a history of surgery in the gastrointestinal system in the past two weeks history of extrapyramidal manifestations
- patients with electrolyte imbalance
- pregnant patients,
Exclusion Criteria
Not provided
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Group I Neostigmine received neostigmine 1 mg Group II Neostigmine received neostigmine 2 mg
- Primary Outcome Measures
Name Time Method The risk of aspiration december 2022 to may 2024 The risk of aspiration in ICU patients on enteral feeding via vaso-gastric or oro-hastric tubes
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Al-Azhar faculty of medicine
🇪🇬Cairo, Egypt