Effect of Two Different Doses of Neostigmine on the Gastric Residual Volume and Aspiration in Critically Ill Patients Under Enteral Feeding; a Comparative Controlled Randomized Trial
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 3
- 试验地点
- 1
- 主要终点
- The risk of aspiration
研究概览
简要总结
A study comparing the effect of two doses of neostigmine on the gastric residual volume in critically ill patients on enteral feeding.
详细描述
Participants were categorized into three groups: Group I and Group II received neostigmine 1 mg and 2 mg, respectively, and a control group received 10 ml of normal saline. All participants received an intravenous administration of 10 mg of metoclopramide. GRV was measured every 3 hours before enteral feeding. aspiration through nasogastric (NG) or orogastric (OG) tubes was done before the next due bolus of feeding.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 20 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients with a GRV >120ml
- •a normal heart rateExclusion Criteria
- •absence of comorbidities such as diabetes and renal failure. exclusion Criteria:
- •Patients exhibiting new-onset arrhythmias or heart block
- •hypotension (systolic blood pressure less than 60 mmHg)
- •experiencing active gastrointestinal bleeding or receiving prokinetic medications 8-12 hours before the intervention
- •patients with a history of surgery in the gastrointestinal system in the past two weeks history of extrapyramidal manifestations
- •patients with electrolyte imbalance
- •pregnant patients,
排除标准
- 未提供
研究组 & 干预措施
Group I
received neostigmine 1 mg
干预措施: Neostigmine (Drug)
Group II
received neostigmine 2 mg
干预措施: Neostigmine (Drug)
结局指标
主要结局
The risk of aspiration
时间窗: december 2022 to may 2024
The risk of aspiration in ICU patients on enteral feeding via vaso-gastric or oro-hastric tubes
次要结局
未报告次要终点