Thermal Quantitative Sensory Testing as a Method to Semi-quantitatively Assess the Neurosensory Effects of 3 Local Anesthetic Solutions in an Interscalene Block
Trial Snapshot
- Phase
- Phase 4
- Status
- Completed
- Sponsor
- University Hospital, Antwerp
- Enrollment
- 45
- Locations
- 1
- Primary Endpoint
- Presence of sensory block
Study Overview
Brief Summary
Thermal quantitative sensory testing (QST) is a method to evaluate peripheral nerve blocks in a quantitative way. It assesses the neurosensory effects of local anesthetics, like nerve block intensity, duration, recovery, neurotoxicity, the effect of spread of local anesthetic solutions and the effect and the eventual neurotoxicity of adjuvants. We aimed at investigating, in a quantitative way, the block characteristics of 3 different commonly used local anesthetics on peripheral nerves through the application of thermal QST by measuring changes in sensory detection thresholds. Furthermore, we wanted to evaluate if QST could be of value for measuring gradual changes in block characteristics on the adjacent nerves at distance of the injection site in an US-ISB.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Masking
- Triple (Participant, Care Provider, Investigator)
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Adult patients scheduled for diagnostic and therapeutic shoulder arthroscopy, with or without decompression technique were eligible
Exclusion Criteria
- •contraindications for ISB
- •diabetes mellitus
- •peripheral neuropathy
- •patients receiving chronic analgesic therapy
- •contraindications for NSAID
- •patients with an initial QST with abnormal values
Arms & Interventions
Levobupivacaine 0,5%
Levobupivacaine 0,5% 15 ml once
Intervention: Interscalene block (Procedure)
Levobupivacaine 0,5% with epinephrine
Levobupivacaine 0,5% with 1/200000 epinephrine 15 ml once
Intervention: Interscalene block (Procedure)
Ropivacaine 0,75%
Ropivacaine 0,75% 15 ml once
Intervention: Interscalene block (Procedure)
Outcomes
Primary Outcomes
Presence of sensory block
Time Frame: 24 hours after intervention
Secondary Outcomes
- Block duration(24 hours after intervention)
- Degree of sensory stimulus detection threshold variation from baseline values(24 hours after intervention)
- Presence of motor block(24 hours after intervention)
- Use of rescue medication(24 hours after intervention)
Investigators
Ethisch Comité UZ Antwerpen
Thermal Quantitative Sensory Testing as a method to semi-quantitatively assess the neurosensory effects of 3 local anesthetic solutions in an interscalene block
University Hospital, Antwerp