Role of certain Ayurvedic Drugs in the management of kidney stone
- Conditions
- Urolithiasis,
- Registration Number
- CTRI/2015/02/005488
- Lead Sponsor
- Central Council for Research in Ayurvedic Sciences CCRAS
- Brief Summary
*Mutrasmari* (urolithiasis) is the condition where urinary [calculi](http://en.wikipedia.org/wiki/Calculus_(medicine) "Calculus (medicine)") are formed or located anywhere in the [urinary system](http://en.wikipedia.org/wiki/Urinary_system "Urinary system"), or the process of forming stones in the kidney, bladder, and/or ureters (urinary tract). *Mutrasmari* is a common cause of haematuria, abdominal pain, pain in flank, or groin. It occurs in one in 20 people at some time in their lives. The stones form in the urine-collecting area (the pelvis) of the kidney and may range in size from tiny to staghorn stones the size of the renal pelvis itself. In Ayurveda, *asmari* is described as one of *Mahagada*. In industrialized countries 10% of men and 3% of women have the problem of *Mutrasmari*. It occurs in people aged 35-45 years, but the disease can affect anyone at any age. xml:namespace prefix = o ns = "urn:schemas-microsoft-com:office:office" /
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During recent decades, pharmacologic intervention has become more effective in stone disease: drugs can control the pain of renal colic, interfere at various levels in development of *Mutrasmari*, and contribute to the expulsion of stones. It is well known that development of *Mutrasmari* is a multifactorial process influenced by environmental-nutritional factors (low urinary volume, diet rich in animal protein, etc) and metabolic alterations; i.e., hypercalciuria, hyperuricosuria, and deficiency of stone-inhibiting factors (citrate, magnesium, glycosaminoglycans [GAGs]). Specific drugs such as citrate, allopurinol, and thiazide represent highly effective treatments for the promoting factors. Surgical approaches like extracorporeal shockwave lithotripsy (SWL) and endourologic techniques are also common practices, now-a-days in its treatment.
Ayurvedic medicines have been used since ancient times for the prevention and treatment of various diseases in human. Treatment of *Mutrasmari* in Ayurveda is an established therapy and free from operational hazards. It is the best alternative to lithotripsy (expensive) and operation. The stone size which is less than 7mm Ayurvedic drugs are very effective due to the litholytic property. This is proved by several research works. In the present study, clinical evaluation of *Goksura churna* and *Sveta* *parpati* in the patients of *Mutrasmari* will be carried out. These Ayurvedic drugs are very cost-effective, low risk (associated with mortality and morbidity) and not required for admission in the hospital.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Not Yet Recruiting
- Sex
- All
- Target Recruitment
- 100
- Age: Between 20-70 years 2.
- Sex: Either sex 3.
- Any three of the following signs and symptoms if present i.
- Intermittant dull/colicky pain in back radiating from loin to groin, which increase on movements/ jerks ii.
- Haematuria iii.
- Frequency of micturition iv.Burning micturition 4.
- Evidence of calculus as per modern diagnostic procedures (Evidence of urolithiasis in any of the following) -CT abdomen non-contrast -U.S.G. KUB region -Stone size <7mm.
1.Age: Below 20 and above 70 years 2.Serum creatinine 1.5mg% 3.Stag horn renal stone 4.Hydronephrosis 5.Pyelonephritis 6.Diabetes mellitus 7.Malignancy 8.Chronic renal failure 9.Severe urinary tract infection or any other infection 10.Impaired renal function 11.Any other complications of calculus.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Decrease in the size of calculus or expulsion of calculus 3 months
- Secondary Outcome Measures
Name Time Method Changes in the clinical sign & symptoms of Mutrasmari (Urolithiasis) 3 years
Trial Locations
- Locations (1)
National Veterinary Ayurveda Research Institute and Hospital Lucknow
🇮🇳Lucknow, UTTAR PRADESH, India
National Veterinary Ayurveda Research Institute and Hospital Lucknow🇮🇳Lucknow, UTTAR PRADESH, IndiaDr Sanjay Kumar SinghPrincipal investigator9532013013drsksingh2005@yahoo.co.in