Subarachnoid haemorrhage (SAH): brain damage, cognitive and behavioral functioning as predictors of recovery.

Recruiting

Conditions: intracranial haemorrhage
subarachnoid haemorrhage
10002363

Registration Number: NL-OMON54915

Lead Sponsor: niversitair Medisch Centrum Groningen

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Not specified

Target Recruitment: 235

Inclusion Criteria

1. A SAH patient, the diagnosis being based on clinical features in combination
with CT angiography (CTA) or digital subtraction angiography (DSA).
2. The patient must be able to understand the instructions of the
neuropsychological assessment and be mentally and physically able to undergo
the research activities; this will be assessed in a consultation between the
treating doctor (neurosurgeon) and researcher (neuropsychologist).
3. Sufficient knowledge of the Dutch language.
4. Age 18 or older

Exclusion Criteria

A limited physical and/or cognitive condition which makes it impossible for
patients to undergo the neuropsychological assessment and MRI.

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The primary outcome measure consists of the score on the Impact on<br /><br>Participation and Autonomy (IPA) (Cardol, 2005) questionnaire 1 year after SAH.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>- The score on the IPA 2 years after SAH;<br /><br>- The score on the mRS 1 and 2 years after SAH;<br /><br>- Performance on neuropsychological tests (intelligence, memory, attention,<br /><br>mental speed, language, visuoconstruction skills, executive functions and<br /><br>social cognition);<br /><br>- Scores on questionnaires (complaints, fatigue, anxiety/depression, stress,<br /><br>coping, personality, behavior, quality of life)<br /><br>- Neuro-imaging outcomes (RS-fMRI, DWI, VBM)<br /><br>o ASL/VAI: cerebral blood flow (CBF), cerebral blood volume (CBV), vessel size,<br /><br>oxygen saturation, vessel architecture<br /><br>o DTI: fractional anisotropy (FA) en apparent diffusion coefficient (ADC)<br /><br>o SWI/QSM: affected tissue volume en hemosiderosis volume<br /><br>o Synthetic MRI: quantitative T1, T2, proton density (PD) values.</p><br>