Understanding Oxytocin's Neural and Behavioral Effects in Adolescents Diagnosed With Autism
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 58
- 主要终点
- The change in social-related neural components (time-locked neural activity) with and without oxytocin
研究概览
简要总结
The investigators explored the neural and behavioral effect of oxytocin on youth with Autism spectrum disorder using magnetoencephalography (MEG). The investigators hypothesize that oxytocin will modulate neural activity to resemble patterns observed in the age-matched control group.
Thirty-two adolescents with autism and 26 typically developing adolescents participated in this randomized, double-blind MEG study. Individuals with autism arrived at the lab twice and received an acute dose of intranasal oxytocin or placebo in each session. During the scans, participants were asked to complete several tasks related to social perception - such as identification of social and non-social stimuli.
详细描述
In the current study, the investigators aimed to explore oxytocin's influences on neural components that relate to social processing. Namely, we focused on M100, M170, and M250, which tend to show atypical patterns in individuals with autism.
The investigators also examined the effects of oxytocin on time dynamics - the change in specific oscillation over time and its effects on neural connectivity patterns.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Triple (Participant, Care Provider, Investigator)
入排标准
- 年龄范围
- 12 Years 至 18 Years（Child, Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Males, aged 12-18 years
- •Native Hebrew speakers
- •Normal or corrected-to-normal vision
- •Participants in the ASD group had to meet the criteria for ASD in the diagnostic and statistical manual of mental disorders (DSM-5)
排除标准
- •Chronic medical problems
- •Cardiovascular risk factors
- •CNS disease
- •Other mental illnesses
- •Use of prohibited medications
- •Mental retardation
- •Impaired vision
- •Impaired hearing
- •History of significant head injury or neurological illness
- •Current substance dependence diagnosis
- •Metallic implants, braces or devices in the body
结局指标
主要结局
The change in social-related neural components (time-locked neural activity) with and without oxytocin
时间窗: During each session
The amplitude (tesla) of three social related neural components will be measured using MEG device
次要结局
- The change in oscillatory activity - power magnitude of Delta, Theta, Alpha, Beta and Gamma neural bands with and without oxytocin(During each session)
- The change in behavioral measurments - reaction times and accurecy rates, with and without oxytocin(During each session)
研究者
Prof. Ilanit gordon
Principal Investigator
Bar-Ilan University, Israel