Role of the Inflammatory Receptors in the Pathogenesis of Atherosclerosis
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 50
- 主要终点
- Level of the inflammatory receptors
研究概览
简要总结
The primary objective of this study is to assess whether inflammatory receptors play a role in the pathogenesis of atherosclerosis.
详细描述
Atherosclerosis is a chronic inflammatory disease characterized by lipid deposition and macrophages/foam cell accumulation beneath the arterial intima. Immune competent cells are abundant in atherosclerotic lesions, where they produce mainly proinflammatory cytokines. Macrophages play a central role in each stage of the pathogenesis of atherosclerosis. At the beginning, the so-called foam cells contribute to the formation of early lesions; in mature plaques, macrophages constitute 50% of the cells in the lesion; finally, they are involved in the mechanisms leading to plaque rupture.
The primary objective of this study is to assess whether the inflammatory receptors play a role in the pathogenesis of atherosclerosis.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •ST-elevation myocardial infarction
- •Angiographic evidence of massive thrombosis in the culprit artery
- •Indication to primary percutaneous coronary intervention (PCI)
- •Able to understand and willing to sign the informed CF
排除标准
- •Women of child bearing potential patients must demonstrate a negative pregnancy test performed within 24 hours before CT
- •Study Population 2 Patients with coronary artery disease in stable conditions scheduled to undergo elective percutaneous coronary intervention and patients with
- •Inclusion Criteria:
- •A de novo native coronary artery lesions (reference vessel diameter:2.5-3.75 mm)
- •Class I indication to elective percutaneous coronary intervention
- •Stable conditions and no recent acute coronary syndromes
- •Normal baseline values of markers of myocardial damage (creatine kinase, creatine kinase-MB, myoglobin, and troponin I)
- •Able to understand and willing to sign the informed CF
- •Exclusion Criteria:
- •Women of child bearing potential patients must demonstrate a negative pregnancy test performed within 24 hours before CT
结局指标
主要结局
Level of the inflammatory receptors
时间窗: Baseline
Determination of plasmatic level of the inflammatory receptors
次要结局
- Fibrinogen(Up to 24 hours after PCI)
- C-reactive protein (CPR)(Up to 24 hours after PCI)
- Plasminogen activator inhibitor (PAI-1)(Up to 24 hours after PCI)
研究者
Francesco Pelliccia
Assistant Professor
University of Roma La Sapienza