Post-conditioning to Reduce Infarct Size
Not Applicable
Completed
- Conditions
- Myocardial Infarction
- Interventions
- Procedure: Post-conditioning
- Registration Number
- NCT00755469
- Lead Sponsor
- Minneapolis Heart Institute Foundation
- Brief Summary
When angioplasty (PTCA) and stenting of the blood vessels of the heart is the treatment for a Heart Attack, there is damage to the heart muscle that is caused by the sudden opening of the blood vessels. This is called "reperfusion injury". The cell death is due to inflammation and the generation of free radicals.
The primary objective of this study is to determine if post-conditioning(four brief (30 second) PTCA balloon inflations) reduces damage to the heart muscle. This will be measured by heart enzyme tests-CK measurements- and by cardiac MRI.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 43
Inclusion Criteria
- Age ≥ 18 < 80
- Able to give informed consent
- 100% occlusion of a major epicardial vessel with TIMI 0 Flow
Exclusion Criteria
- Significant collateral blood flow to the distal vasculature of the occluded vessel.
- Previous CABG
- Previous q-wave myocardial infarction in the same territory
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description 1 Post-conditioning -
- Primary Outcome Measures
Name Time Method Infarct size, determined by late-enhancement measurements of the LV using gadolinium contrast with cardiac MRI 3 months
- Secondary Outcome Measures
Name Time Method The degree of Microvascular Obstruction (MVO), as measured by Cardiac MRI 3 months
Trial Locations
- Locations (1)
Abbott Northwestern Hospital
🇺🇸Minneapolis, Minnesota, United States