NCT00755469已完成不适用
Modification of Reperfusion by "Post-Conditioning" Reduces Infarct Size in Acute Myocardial Infarction
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 43
- 试验地点
- 2
- 主要终点
- Infarct size, determined by late-enhancement measurements of the LV using gadolinium contrast with cardiac MRI
研究概览
简要总结
When angioplasty (PTCA) and stenting of the blood vessels of the heart is the treatment for a Heart Attack, there is damage to the heart muscle that is caused by the sudden opening of the blood vessels. This is called "reperfusion injury". The cell death is due to inflammation and the generation of free radicals.
The primary objective of this study is to determine if post-conditioning(four brief (30 second) PTCA balloon inflations) reduces damage to the heart muscle. This will be measured by heart enzyme tests-CK measurements- and by cardiac MRI.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age ≥ 18 < 80
- •Able to give informed consent
- •100% occlusion of a major epicardial vessel with TIMI 0 Flow
排除标准
- •Significant collateral blood flow to the distal vasculature of the occluded vessel.
- •Previous CABG
- •Previous q-wave myocardial infarction in the same territory
结局指标
主要结局
Infarct size, determined by late-enhancement measurements of the LV using gadolinium contrast with cardiac MRI
时间窗: 3 months
次要结局
- The degree of Microvascular Obstruction (MVO), as measured by Cardiac MRI(3 months)
研究者
研究点 (2)
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