EEG Outcomes From Cognitive Behavioural Therapy for Psychosis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 20
- 试验地点
- 2
- 主要终点
- Positive and Negative Syndrome Scale (PANSS) Total Score
研究概览
简要总结
Despite overwhelming evidence for neurocognitive and neurophysiological factors involved in the etiology of psychosis, these factors have never been examined as mechanisms of improvement from CBTp. The first aim in the present study is to examine neurophysiological outcomes from CBTp using electroencephalography (EEG). The second aim is to examine neurocognitive outcomes from CBTp. This is an open-label pilot study. Twenty participants will receive CBTp and will be assessed at baseline and after 4 months.
详细描述
Despite decades of refining traditional treatments for schizophrenia-spectrum disorders, recovery rates remain unchanged at only 13.5%, and there is an urgent need for innovative new interventions. Cognitive behavioural therapy has more recently been applied to treating psychosis and initial evidence has suggested that cognitive behavioural therapy for psychosis (CBTp) is the most effective psychosocial intervention available for psychosis. However, the efficacy of CBTp has been limited to moderate effect sizes. Little is currently understood about the mechanisms of CBTp, and a greater understanding of mechanisms is necessary in order to improve treatment efficacy. Despite overwhelming evidence for neurocognitive and neurophysiological factors involved in the etiology of psychosis, these factors have never been examined as mechanisms of improvement from CBTp. Cognitive behavioural therapy for psychosis (CBTp) has demonstrated efficacy for reducing positive symptoms, negative symptoms, and improving community functioning6 for individuals diagnosed with psychotic disorders. Despite meta-analytic evidence for the efficacy of CBTp, little is known about the neurophysiological processes through which symptomatic and functional change occurs. Electroencephalography (EEG) provides temporally precise measurement of neurophysiological activity. Positive symptoms have been associated with reduced integration of discrepant information as indexed by the N400 event-related potential, reduced resting state power in the EEG alpha frequency band, and reduced cognitive control as indexed by EEG alpha and theta power during cognitive flanker tasks. Additionally, neurocognitive abilities such as attention, memory, and problem solving are the best predictors of community functioning among individuals diagnosed with psychotic disorders. Although CBTp improves community functioning,[6] neurophysiological and neurocognitive outcomes have never been examined as therapeutic mechanisms from CBTp, despite the fact that therapeutic processes would be expected to improve cognitive functions.
Aim 1: Examine neurophysiological outcomes from CBTp using EEG.
Aim 2: Examine neurocognitive outcomes from CBTp
Hypothesis 1: After CBTp it is expected that participants will have a) increased N400 amplitude; b) increased resting state EEG alpha power; and c) reduced alpha and increased theta power during a flanker task
Hypothesis 2: After CBTp participants will have increased global neurocognitive abilities as indexed by a neurocognitive composite score.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •The inclusion criteria is anyone who meets the criteria of schizophrenia, schizoaffective disorder or any other psychotic disorder, are also 18-65 years of age, are not abusing drugs or alcohol and can read and speak English. Participants must be experiencing active symptoms of psychosis as indicated on the PANSS.
排除标准
- •Exclusion criteria include anyone with a neurological disease or neurological damage, medical illnesses that can change neurocognitive function, a medical history of head injury with loss of consciousness and those with physical handicaps that would prevent them from engaging in assessment procedures
结局指标
主要结局
Positive and Negative Syndrome Scale (PANSS) Total Score
时间窗: Change from Baseline to Follow-up (6 months post treatment)
The PANSS is a 30-item semi-structured interview assessing positive, negative symptoms and general psychopathology. Each item is scored on a 7-point scale (1 = absent, 2 = minimal, 3 = mild, 4 = moderate, 5 = moderate severe, 6 = severe, 7 = extreme). The lowest score would be a 30 and the highest score would be 210. A higher score would indicate increased symptomology.
次要结局
- Brief Core Schema Scale (BCSS)(Change from Baseline to Follow-up (6 months post treatment))
- Working Alliance Inventory (WAI)(Change from Baseline to Follow-up (6 months post treatment))
- Personal and Social Performance Scale (PSP)(Change from Baseline to Follow-up (6 months post treatment))
- The Questionnaire About the Process of Recovery (QPR)(Change from Baseline to Follow-up (6 months post treatment))
- Experiences Questionnaire (EQ)(Change from Baseline to Follow-up (6 months post treatment))
- Childhood Trauma Questionnaire (CTQ)(Change from Baseline to Follow-up (6 months post treatment))
- Beliefs About Paranoia Scale (BAPS)(Change from Baseline to Follow-up (6 months post treatment))
- Dysfunctional Attitude Scale (DAS)(Change from Baseline to Follow-up (6 months post treatment))
- Psychological Distance Scaling Task (PDST)(Change from Baseline to Follow-up (6 months post treatment))
- The Psychotic Symptom Rating Scales (PSYRATS)(Change from Baseline to Follow-up (6 months post treatment))
- Calgary Depression Scale for Schizophrenia (CDSS)(Change from Baseline to Follow-up (6 months post treatment))
- Beliefs About Voices Questionnaire (BAVQ)(Change from Baseline to Follow-up (6 months post treatment))
- Davos Assessment of Cognitive Biases Scale (DACOBS)(Change from Baseline to Follow-up (6 months post treatment))
研究者
Michael Best
Assistant Professor
University of Toronto