Effect of Electrostimulation in Chronic Obstructive Pulmonary Disease (COPD)
- Conditions
- Chronic Obstructive Pulmonary Disease
- Registration Number
- NCT01167283
- Lead Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
- Brief Summary
This study was designed to test the following hypothesis:
To investigate whether COPD muscles can respond to stimuli in terms of changes in fiber-type distribution.
- Detailed Description
Background: Muscle dysfunction is a major problem in chronic obstructive pulmonary disease (COPD). It is characterized by muscle fiber-type redistribution and oxidative stress. Classical training does not improve these features.
Objectives: To investigate whether electrostimulation program following exacerbation can modify muscle structure and function in COPD patients.
Method: We propose to conduct a controlled and randomized clinical trial comparing the efficacy of muscle electrostimulation training of the lower limbs to sham training in 15 patients with COPD. Patients are included in either 6 weeks of electrostimulation training (active treatment group) or 6 weeks of sham electrostimulation. Primary outcomes were changes in muscle structure, muscle oxidative stress and their relationship with quadriceps force and exercise tolerance.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 15
- COPD patients during or after exacerbation
- Comorbidities that could limit exercise training
- Obesity (body mass index [BMI] > 30 kg/m²)
- Neuromuscular disease
- Pacemaker implantation
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Fiber-type distribution 6 to 8 weeks Typology was evaluated by immunohistochemistry
- Secondary Outcome Measures
Name Time Method Change in the strength of the quadriceps over the 6-week electrostimulation program 6 to 8 weeks