Effect of Electromyostimulation in Severe Chronic Obstructive Pulmonary Disease
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Chronic Obstructive Pulmonary Disease
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
- Enrollment
- 15
- Primary Endpoint
- Fiber-type distribution
- Status
- Completed
- Last Updated
- 15 years ago
Overview
Brief Summary
This study was designed to test the following hypothesis:
To investigate whether COPD muscles can respond to stimuli in terms of changes in fiber-type distribution.
Detailed Description
Background: Muscle dysfunction is a major problem in chronic obstructive pulmonary disease (COPD). It is characterized by muscle fiber-type redistribution and oxidative stress. Classical training does not improve these features. Objectives: To investigate whether electrostimulation program following exacerbation can modify muscle structure and function in COPD patients. Method: We propose to conduct a controlled and randomized clinical trial comparing the efficacy of muscle electrostimulation training of the lower limbs to sham training in 15 patients with COPD. Patients are included in either 6 weeks of electrostimulation training (active treatment group) or 6 weeks of sham electrostimulation. Primary outcomes were changes in muscle structure, muscle oxidative stress and their relationship with quadriceps force and exercise tolerance.
Investigators
Eligibility Criteria
Inclusion Criteria
- •COPD patients during or after exacerbation
Exclusion Criteria
- •Comorbidities that could limit exercise training
- •Obesity (body mass index \[BMI\] \> 30 kg/m²)
- •Neuromuscular disease
- •Pacemaker implantation
Outcomes
Primary Outcomes
Fiber-type distribution
Time Frame: 6 to 8 weeks
Typology was evaluated by immunohistochemistry
Secondary Outcomes
- Change in the strength of the quadriceps over the 6-week electrostimulation program(6 to 8 weeks)