Effect of Electromyostimulation in Severe Chronic Obstructive Pulmonary Disease
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Enrollment
- 15
- Primary Endpoint
- Fiber-type distribution
Study Overview
Brief Summary
This study was designed to test the following hypothesis:
To investigate whether COPD muscles can respond to stimuli in terms of changes in fiber-type distribution.
Detailed Description
Background: Muscle dysfunction is a major problem in chronic obstructive pulmonary disease (COPD). It is characterized by muscle fiber-type redistribution and oxidative stress. Classical training does not improve these features.
Objectives: To investigate whether electrostimulation program following exacerbation can modify muscle structure and function in COPD patients.
Method: We propose to conduct a controlled and randomized clinical trial comparing the efficacy of muscle electrostimulation training of the lower limbs to sham training in 15 patients with COPD. Patients are included in either 6 weeks of electrostimulation training (active treatment group) or 6 weeks of sham electrostimulation. Primary outcomes were changes in muscle structure, muscle oxidative stress and their relationship with quadriceps force and exercise tolerance.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Masking
- Single (Participant)
Eligibility Criteria
- Ages
- 50 Years to 80 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •COPD patients during or after exacerbation
Exclusion Criteria
- •Comorbidities that could limit exercise training
- •Obesity (body mass index [BMI] > 30 kg/m²)
- •Neuromuscular disease
- •Pacemaker implantation
Outcomes
Primary Outcomes
Fiber-type distribution
Time Frame: 6 to 8 weeks
Typology was evaluated by immunohistochemistry
Secondary Outcomes
- Change in the strength of the quadriceps over the 6-week electrostimulation program(6 to 8 weeks)