Long-term Oncologic Outcome of Breast-conserving Surgery in Breast Cancer Patients With BRCA1/2 Mutations
- Conditions
- BRCA1/2 MutationBreast-conserving Surgery
- Interventions
- Procedure: Breast-conserving surgery
- Registration Number
- NCT06429644
- Lead Sponsor
- Hanyang University Seoul Hospital
- Brief Summary
The investigators matched BCS and mastectomy group using propensity scores and analyzed the recurrence and survival among the evenly matched patients in breast cancer patients with BRCA 1/2 mutations.
- Detailed Description
The purpose of study is to assess the oncologic safety of BCS in patients carrying BRCA1/2 mutations by comparing long-term outcomes with mastectomy. The investigators matched BCS and mastectomy group using propensity scores and analyzed the recurrence and survival among the evenly matched patients. By providing insights into the feasibility of BCS for patients with BRCA1/2 mutations, the investigators aim to present evidence to aid in surgical decision-making for the care of these patients.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 4010
- Primary invasive breast cancer who underwent BCS or mastectomy
- Received a BRCA1/2 mutation test
- Patients with de novo metastasis
- Pregnancy-associated breast cancer
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Gangnam Severance Hospital Breast-conserving surgery Department of Surgery, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea Incheon St. Mary's Hospital Breast-conserving surgery Department of Surgery, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Incheon, Republic of Korea Kyung Hee University Hospital Breast-conserving surgery Department of Surgery, Kyung Hee University Hospital, Seoul, Republic of Korea Asan Medical Center Breast-conserving surgery Division of Breast Surgery, Department of Surgery, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea Dongtan Sacred Heart Hospital Breast-conserving surgery Department of Surgery, Dongtan Sacred Heart Hospital, Hallym University, Dongtan, Republic of Korea Samsung Medical Center Breast-conserving surgery Division of Breast Surgery, Department of Surgery, Sungkyunkwan University School of Medicine, Samsung Medical Center, Seoul, Republic of Korea Severance hospital Breast-conserving surgery Department of Surgery, Severance hospital, Yonsei University College of Medicine, Seoul, Republic of Korea Hanyang University Medical Center Breast-conserving surgery Department of Surgery, Hanyang University Medical Center, Hanyang University College of Medicine, Seoul, Republic of Korea Hallym University Sacred Heart Hospital Breast-conserving surgery Department of Breast \& Endocrine Surgery, Hallym University Sacred Heart Hospital, Hallym University, Anyang, Republic of Korea Kangbuk Samsung Hospital Breast-conserving surgery Department of Surgery, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea Seoul National University Hospital Breast-conserving surgery Breast Care Center, Department of Surgery, Seoul National University Hospital, Seoul, Republic of Korea Kyungpook National University Chilgok Hospital Breast-conserving surgery Department of Surgery, School of Medicine, Kyungpook National University, Kyungpook National University Chilgok Hospital, Daegu, Republic of Korea Keimyung University School of Medicine Breast-conserving surgery Department of Surgery, Keimyung University School of Medicine, Daegu, Republic of Korea
- Primary Outcome Measures
Name Time Method Locoregional recurrence-free survival Duration from diagnosis until the development of recurrence up to 10year Recurrence in breast or chest wall and/or regional lymph nodes
Distant recurrence-free survival Duration from diagnosis until the development of recurrence up to 10year Recurrence in a distant organ
Recurrence-free survival Duration from diagnosis until the development of recurrence up to 10year Any form of disease recurrence
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Hanyang university hospital
🇰🇷Seoul, Korea, Republic of