Associations of circulating elastin degradation products (iso)desmosine with other blood biomarkers, CT-densitometry, arterial stiffness, lung function parameters, and copper in exhaled breath condensate

Recruiting

Conditions: ongparenchym: emfyseem
COPD (chronic obstructive pulmonary disease)
Emphysema
10038716
10003216

Registration Number: NL-OMON45757

Lead Sponsor: Canisius Wilhelmina Ziekenhuis

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Not specified

Target Recruitment: 40

Inclusion Criteria

- COPD Gold I-IV with emphysema on CT thorax
- Willful patient
- Age 18-75 years
- COPD set according to the GOLD criteria; FEV1 / FVC ratio <0.7,
- history of nicotine abuses> 10 pack / years
- Radiologically determined emphysema
- Able to undergo a CT scan
- Able to undergo lung function examination
- Prepared to prick blood
- Able to undergo respiratory condensate collection

Exclusion Criteria

- Unstable cardiac situation
- (active) malignancy
- Interstitial lung disease
- Status after lung surgery (lobectomy/pneumonectomy)
- Pregnancy
- Alpha-1 antitrypsin deficiency (MZ is allowed, but PI*ZZ, PI*Z/zero and PI*zero/zero is not allowed)

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Primary objective:<br /><br>- Correlation of pDES level with CT-longdensitometrie</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary objectives:<br /><br>- Correlation of pDES level with PWV<br /><br>- Correlation of pDES level with lung function tests<br /><br>- Correlation of pDES level with blood biomarkers<br /><br>- Correlation of pDES level with copper concentration in exhalation vapor<br /><br>condensate<br /><br>- Correlation of pDES level with degree of vascular calcification at the site<br /><br>of the carotid siphon artery<br /><br>- Correlation of other biomarkers with each other, CT-lung densitometry, PWV,<br /><br>lung function tests and degree of vascular calcification. the a. carotis siphon</p><br>