euroinvasion in COVID-19
Suspended
- Conditions
- COVID-19
- Registration Number
- NL-OMON23627
- Lead Sponsor
- Zuyderland Medical Centre
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Suspended
- Sex
- Not specified
- Target Recruitment
- 10
Inclusion Criteria
At least 18 years of age
-Requires mechanical ventilation
-Proven SARS-CoV-2 infection
-Lumbar puncture possible within 48 hours of ICU admission
-Informed consent provided by either patient or legal representative
Exclusion Criteria
-Contraindication for lumbar puncture
-Proven or suspected cerebrospinal fluid leak or other blood-brain barrier defects
-Any condition known to alter cerebrospinal fluid biochemistry
-Known or suspected cause for respiratory failure, other than COVID-19
-Any disease known for decreasing pulmonary capacity or compliance
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method SARS-CoV-2 RT-PCR of cerebrospinal fluid
- Secondary Outcome Measures
Name Time Method -8-week mortality<br>-Leukocyte count of the cerebrospinal fluid<br>-Serum Leukocyte count, C-reactive protein, Lactate dehydrogenase, D-Dimer