跳至主要内容
临床试验/NCT05701852
NCT05701852招募中不适用

Motivational Behavioral and Functional MRI Impairment in Patients With Chronic Neuropathic Pain

Fondation Ophtalmologique Adolphe de Rothschild1 个研究点 分布在 1 个国家目标入组 50 人开始时间: 2023年12月19日最近更新:
适应症

试验速览

阶段
不适用
状态
招募中
入组人数
50
试验地点
1
主要终点
To compare reward learning ability in patients with chronic neuropathic pain compared with an age (±5 years) and gender-matched control population

研究概览

简要总结

The main hypothesis of this study is that the alteration of the reward circuitry underlying the motivational deficit in chronic pain patients compared to healthy subjects results in a decrease in the capacity for reward learning. The fMRI studies have shown that this type of learning depends on the dopaminergic system innervating key regions of the reward system.

研究设计

研究类型
Observational
观察模型
Case Control
时间视角
Cross Sectional

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • For cases: patients managed in the neurosurgery department or at CETD for chronic neuropathic pain, of central or peripheral origin.
  • For controls: matched to a case on age (±5 years) and sex

排除标准

  • Neurodegenerative or inflammatory neurological pathology
  • Clinical depressive syndrome
  • High doses of opioid treatment (greater than 100 mg/day of morphine equivalent)
  • Impaired judgment or inability to receive information that does not allow the performance of behavioral tasks
  • Absolute contraindication to MRI (e.g. pacemaker, implantable pacemaker, metallic intra-orbital foreign body)

结局指标

主要结局

To compare reward learning ability in patients with chronic neuropathic pain compared with an age (±5 years) and gender-matched control population

时间窗: Day 0

the reward learning ability will be assessed using a specific task. The result of the task questionnaire is a numeric score.

次要结局

未报告次要终点

研究者

申办方类型
Network
责任方
Sponsor

研究点 (1)

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