NCT05701852RecruitingNot Applicable
Motivational Behavioral and Functional MRI Impairment in Patients With Chronic Neuropathic Pain
Fondation Ophtalmologique Adolphe de Rothschild1 site in 1 country50 target enrollmentStarted: December 19, 2023Last updated:
Conditions
Trial Snapshot
- Phase
- Not Applicable
- Status
- Recruiting
- Enrollment
- 50
- Locations
- 1
- Primary Endpoint
- To compare reward learning ability in patients with chronic neuropathic pain compared with an age (±5 years) and gender-matched control population
Study Overview
Brief Summary
The main hypothesis of this study is that the alteration of the reward circuitry underlying the motivational deficit in chronic pain patients compared to healthy subjects results in a decrease in the capacity for reward learning. The fMRI studies have shown that this type of learning depends on the dopaminergic system innervating key regions of the reward system.
Study Design
- Study Type
- Observational
- Observational Model
- Case Control
- Time Perspective
- Cross Sectional
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •For cases: patients managed in the neurosurgery department or at CETD for chronic neuropathic pain, of central or peripheral origin.
- •For controls: matched to a case on age (±5 years) and sex
Exclusion Criteria
- •Neurodegenerative or inflammatory neurological pathology
- •Clinical depressive syndrome
- •High doses of opioid treatment (greater than 100 mg/day of morphine equivalent)
- •Impaired judgment or inability to receive information that does not allow the performance of behavioral tasks
- •Absolute contraindication to MRI (e.g. pacemaker, implantable pacemaker, metallic intra-orbital foreign body)
Outcomes
Primary Outcomes
To compare reward learning ability in patients with chronic neuropathic pain compared with an age (±5 years) and gender-matched control population
Time Frame: Day 0
the reward learning ability will be assessed using a specific task. The result of the task questionnaire is a numeric score.
Secondary Outcomes
No secondary outcomes reported
Investigators
Study Sites (1)
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