NCT05701852招募中不适用
Motivational Behavioral and Functional MRI Impairment in Patients With Chronic Neuropathic Pain
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- To compare reward learning ability in patients with chronic neuropathic pain compared with an age (±5 years) and gender-matched control population
研究概览
简要总结
The main hypothesis of this study is that the alteration of the reward circuitry underlying the motivational deficit in chronic pain patients compared to healthy subjects results in a decrease in the capacity for reward learning. The fMRI studies have shown that this type of learning depends on the dopaminergic system innervating key regions of the reward system.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •For cases: patients managed in the neurosurgery department or at CETD for chronic neuropathic pain, of central or peripheral origin.
- •For controls: matched to a case on age (±5 years) and sex
排除标准
- •Neurodegenerative or inflammatory neurological pathology
- •Clinical depressive syndrome
- •High doses of opioid treatment (greater than 100 mg/day of morphine equivalent)
- •Impaired judgment or inability to receive information that does not allow the performance of behavioral tasks
- •Absolute contraindication to MRI (e.g. pacemaker, implantable pacemaker, metallic intra-orbital foreign body)
结局指标
主要结局
To compare reward learning ability in patients with chronic neuropathic pain compared with an age (±5 years) and gender-matched control population
时间窗: Day 0
the reward learning ability will be assessed using a specific task. The result of the task questionnaire is a numeric score.
次要结局
未报告次要终点
研究者
研究点 (1)
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