Characterization of Cardiac Electrophysiological Effects of Autonomic Neuromodulation
Early Phase 1
Recruiting
- Conditions
- Ventricular Tachycardia
- Interventions
- Drug: Stellate Ganglion Block
- Registration Number
- NCT05377216
- Lead Sponsor
- University of Pennsylvania
- Brief Summary
Prospective cohort study evaluating the electrophysiologic and biochemical effects of stellate ganglion block in patients with ventricular tachycardia.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 20
Inclusion Criteria
- Planned catheter based VT ablation
- Age at least 18 years
Exclusion Criteria
- Pregnancy
- Contraindication to SGB or VT ablation
- Hypersensitivity of local anesthetic of amide type
- Hemodynamic instability during the procedure prior to the study protocol
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Stellate ganglion block Stellate Ganglion Block All subjects will undergo stellate ganglion block during their VT ablation procedure
- Primary Outcome Measures
Name Time Method Ventricular Effective Refractory Period 30 minutes following stellate ganglion block Change in Ventricular Effective Refractory Period at 600ms drive train (measured in milliseconds)
- Secondary Outcome Measures
Name Time Method Neuropeptide Y 30 minutes following stellate ganglion block Change in level of neuropeptide Y from baseline (measured in pg/mL)
Ventricular Arrhythmia Inducibility 30 minutes following stellate ganglion block Induction of monomorphic ventricular arrhythmia (binary outcome) during ventricular programmed stimulation
Trial Locations
- Locations (1)
Hospital of the University of Pennsylvania
🇺🇸Philadelphia, Pennsylvania, United States