Skip to main content
MedPathMedPath Home
Clinical Trials/NCT05377216
NCT05377216
Recruiting
Early Phase 1

Characterization of Cardiac Electrophysiological Effects of Autonomic Neuromodulation

University of Pennsylvania1 site in 1 country20 target enrollmentSeptember 1, 2022
Share to TwitterShare to FacebookShare to LinkedInShare to Reddit
ConditionsVentricular Tachycardia
InterventionsStellate Ganglion Block
DrugsStellate Ganglion Block

Overview

Phase
Early Phase 1
Intervention
Stellate Ganglion Block
Conditions
Ventricular Tachycardia
Sponsor
University of Pennsylvania
Enrollment
20
Locations
1
Primary Endpoint
Ventricular Effective Refractory Period
Status
Recruiting
Last Updated
5 months ago
OverviewInvestigatorsEligibility CriteriaArms & InterventionsOutcomesSitesSimilar Trials

Overview

Brief Summary

Prospective cohort study evaluating the electrophysiologic and biochemical effects of stellate ganglion block in patients with ventricular tachycardia.

Registry
clinicaltrials.gov
Start Date
September 1, 2022
End Date
July 1, 2027
Last Updated
5 months ago
Study Type
Interventional
Study Design
Single Group
Sex
All

Investigators

Responsible Party
Sponsor

Eligibility Criteria

Inclusion Criteria

  • •Planned catheter based VT ablation
  • •Age at least 18 years

Exclusion Criteria

  • •Pregnancy
  • •Contraindication to SGB or VT ablation
  • •Hypersensitivity of local anesthetic of amide type
  • •Hemodynamic instability during the procedure prior to the study protocol

Arms & Interventions

Stellate ganglion block

All subjects will undergo stellate ganglion block during their VT ablation procedure

Intervention: Stellate Ganglion Block

Outcomes

Primary Outcomes

Ventricular Effective Refractory Period

Time Frame: 30 minutes following stellate ganglion block

Change in Ventricular Effective Refractory Period at 600ms drive train (measured in milliseconds)

Secondary Outcomes

  • Neuropeptide Y(30 minutes following stellate ganglion block)
  • Ventricular Arrhythmia Inducibility(30 minutes following stellate ganglion block)

Study Sites (1)

Loading locations...

Similar Trials

Not yet recruiting
Not Applicable
To study effect of stellate ganglion block on electrical activity of heart in patients having recent bleeding beneath innermost membrane around brain with constriction in arteries supplying brain- A preliminary study based on Holter monitoring.Health Condition 1: G978- Other intraoperative and postprocedural complications and disorders of nervous system
CTRI/2019/04/018516All India Institute of Medical Sciences New Delhi
Enrolling By Invitation
Not Applicable
Better Mechanistic Understanding of and Risk Stratification for Ventricular Tachyarrhythmias Through ECGIVentricular TachycardiaVentricular ArrythmiaVentricular FibrillationPolymorphic Ventricular TachycardiaSudden Cardiac DeathSudden Cardiac ArrestSudden Cardiac Death Due to Cardiac ArrhythmiaHeart ArrestCardiac DeathCardiac ArrestCardiac ArrhythmiaCongenital Heart Disease
NCT04548804Maastricht University Medical Center270
Completed
Not Applicable
Investigating the Role and Electrophysiological Characteristics of the Human Claustrum Based on SEEGRefractory EpilepsyConsciousness, Loss of
NCT06575413Xuanwu Hospital, Beijing8
Completed
Not Applicable
Effects on various organs in patients who used Remimazolam under general anesthesiaAll patients under general anesthesia
JPRN-UMIN000045998Kindai university faculty of medicine100
Unknown
Not Applicable
Noninvasive Electrocardiographic Imaging for Individuals at Risk for Apparently Idiopathic Ventricular Fibrillation.Ventricular FibrillationVentricular ArrythmiaPolymorphic Ventricular TachycardiaSudden Cardiac DeathHeart ArrestCardiovascular DiseasesCardiac ArrhythmiaGenetic DiseaseIdiopathic Ventricular FibrillationCardiac Arrest
NCT03963271Maastricht University Medical Center500