The effect of pomegranate juice on allergic rhinitis

Not Applicable

• Conditions: Allergic rhinitis.; Allergic rhinitis, unspecified; J30.4

• Registration Number: IRCT20221012056153N1
• Lead Sponsor: Mashhad University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 3 April 2023

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

Allergic rhinitis patients
Patients who have been treated with standard drugs including antihistamines and corticosteroids for at least 4 weeks and have had a poor or no response to these treatments are included in the study.

Exclusion Criteria

Pregnancy or breastfeeding
Patients with non-allergic rhinitis
Patients with systemic diseases
Use of herbal supplements with antioxidant properties
Liver dysfunction (LFT>3ULN)
Kidney dysfunction (GFR<60 ml/kg/min)
Thyroid disorders (based on thyroid function test)
Epilepsy

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Determining the severity of clinical symptoms of patients (including sneezing, an itchy nose, a runny or blocked nose, itchy, red and watery eyes, a cough, the roof of mouth being itchy). Timepoint: Beginning and end of the study (zero and 60 days). Method of measurement: Using of Sino-Nasal Test 20 (SNOT-20).

Secondary Outcome Measures

Name	Time	Method
The level of specific IgE. Timepoint: Beginning and end of the study (zero and 60 days). Method of measurement: Collection of blood samples from patients.;Th1/Th2 cytokines. Timepoint: Beginning and end of the study (zero and 60 days). Method of measurement: Collection of blood samples from patients.;Determination of interferon (IFN)-? concentration. Timepoint: Beginning and end of the study (zero and 60 days). Method of measurement: Collection of blood samples from patients.;Determination of interleukin IL-4 and IL-5 concentrations. Timepoint: Beginning and end of the study (zero and 60 days). Method of measurement: Collection of blood samples from patients.