Phase II Study of Weekly Oxaliplatin With Continous Infusion Fluorouracil And Concurrent Radiation for Treatment of Localised Oesophageal Carcinoma

Phase 2

Recruiting

• Conditions: Histologically confirmed localised squamous cell carcinoma of the oesophagus; Adenocarcinoma of the oesophagus; Cancer - Oesophageal (gullet)

• Registration Number: ACTRN12605000106639
• Lead Sponsor: Princess Alexandra Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2005-08-09
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

1.Histologically confirmed localised squamous cell carcinoma of the oesophagus or adenocarcinoma of the oesophagus. 2. Performance status 0 or 1. 3. No prior chemotherapy or radiotherapy. 4. Disease evaluated by either CT or endoscopy. 5. Geographically accessible. 6. No other severe medical illness which would contra-indicate the therapy. 7. Life expectancy of greater than 3 months. 8. Bone marrow function showing white cells greater than 3.0x109/L, neutrophils greater than 2.0x109/L, platelets greater than 100x109/L. 9. Creatinine less than 2x upper limit of normal. 10.Adequate methods of contraception.

Exclusion Criteria

1. Serious uncontrolled infection 2. Uncontrolled other malignancy 3. Concurrent treatment with other anti-cancer drugs 4. Respiratory function with FEV1 less than 1L 5. Oesophageal-bronchial fistula 6. Pregnancy or Lactation

Study & Design

• Study Type: Interventional
• Study Design: Not specified