The Effect of Vitamin D Supplementation on Vitamin D Status, Immunity and Physical Performance
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Vitamin D Status
- Sponsor
- Bangor University
- Enrollment
- 260
- Locations
- 1
- Primary Endpoint
- Vitamin D status
- Last Updated
- 9 years ago
Overview
Brief Summary
The purpose of this study is to examine the effect of vitamin D supplementation on vitamin D status, immunity and physical performance.
Detailed Description
Vitamin D plays a key role in bone mineralisation and has been linked to immune defence maintenance and muscle function. Vitamin D is primarily obtained from endogenous synthesis in response to skin sunlight exposure and follows a seasonal pattern; whereby, vitamin D levels peak at the end of the summer and fall to a trough during winter. If winter vitamin D levels can be increased to match those found in summer using supplementation, it is proposed sufficient vitamin D levels will improve physical performance and reduce susceptibility to illness in military recruits.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Passed medical assessment by medical doctor
Exclusion Criteria
- •Medically deferred by medical doctor
- •Regular sun bed use
- •Holiday in a hot sunny climate in \<3 months
- •Regular vitamin D supplementation
Outcomes
Primary Outcomes
Vitamin D status
Time Frame: Up to 20 months
Circulating 25-hydroxy-vitamin D, 1,25-d OH(OH)D
Secondary Outcomes
- Physical performance 1(Up to 20 months)
- Physical performance 2(Up to 20 months)
- Physical performance 3(Up to 20 months)
- Hepatitis B antibody(Up to 20 months)
- Mucosal immunity(Up to 20 months)