The Effect of Vitamin D Supplementation on Vitamin D Status, Immunity and Physical Performance
试验速览
- 阶段
- 不适用
- 入组人数
- 260
- 试验地点
- 1
- 主要终点
- Vitamin D status
研究概览
简要总结
The purpose of this study is to examine the effect of vitamin D supplementation on vitamin D status, immunity and physical performance.
详细描述
Vitamin D plays a key role in bone mineralisation and has been linked to immune defence maintenance and muscle function. Vitamin D is primarily obtained from endogenous synthesis in response to skin sunlight exposure and follows a seasonal pattern; whereby, vitamin D levels peak at the end of the summer and fall to a trough during winter. If winter vitamin D levels can be increased to match those found in summer using supplementation, it is proposed sufficient vitamin D levels will improve physical performance and reduce susceptibility to illness in military recruits.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 17 Years 至 35 Years（Child, Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Passed medical assessment by medical doctor
排除标准
- •Medically deferred by medical doctor
- •Regular sun bed use
- •Holiday in a hot sunny climate in <3 months
- •Regular vitamin D supplementation
研究组 & 干预措施
Placebo Oral Vitamin D3
Placebo Oral Vitamin D3
干预措施: Placebo Oral Vitamin D3 (Dietary Supplement)
Solar simulated radiation (SSR)
Solar simulated radiation (SSR)
干预措施: Solar simulated radiation (SSR) (Radiation)
Placebo SSR
Placebo SSR
干预措施: Placebo SSR (Radiation)
Oral Vitamin D3
Oral Vitamin D3
干预措施: Oral Vitamin D3 (Dietary Supplement)
结局指标
主要结局
Vitamin D status
时间窗: Up to 20 months
Circulating 25-hydroxy-vitamin D, 1,25-d OH(OH)D
次要结局
- Physical performance 1(Up to 20 months)
- Physical performance 2(Up to 20 months)
- Physical performance 3(Up to 20 months)
- Hepatitis B antibody(Up to 20 months)
- Mucosal immunity(Up to 20 months)